Guo Wenli, Zhang Jie, Li Wenjun, Xu Ming, Liu Sijin
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
School of Stomatology, Wuhan University, Wuhan 430072, China.
J Environ Sci (China). 2015 Aug 1;34:155-64. doi: 10.1016/j.jes.2015.04.004. Epub 2015 May 25.
Environmental pollution has become one of the greatest problems in the world, and the concerns about environmental pollutants released by human activities from agriculture and industrial production have been continuously increasing. Although intense efforts have been made to understand the health effects of environmental pollutants, most studies have only focused on direct toxic effects and failed to simultaneously evaluate the long-term adaptive, compensatory and secondary impacts on health. Burgeoning evidence suggests that environmental pollutants may directly or indirectly give rise to disordered element homeostasis, such as for iron. It is crucially important to maintain concerted cellular and systemic iron metabolism. Otherwise, disordered iron metabolism would lead to cytotoxicity and increased risk for various diseases, including cancers. Thus, study on the effects of environmental pollutants upon iron homeostasis is urgently needed. In this review, we recapitulate the available findings on the direct or indirect impacts of environmental pollutants, including persistent organic pollutants (POPs), heavy metals and pesticides, on iron homeostasis and associated adverse health problems. In view of the unanswered questions, more efforts are warranted to investigate the disruptive effects of environmental pollutants on iron homeostasis and consequent toxicities.
环境污染已成为世界上最严重的问题之一，人们对农业和工业生产等人类活动所释放的环境污染物的担忧也在不断增加。尽管人们为了解环境污染物对健康的影响付出了巨大努力，但大多数研究仅关注直接毒性作用，未能同时评估其对健康的长期适应性、补偿性和继发性影响。越来越多的证据表明，环境污染物可能直接或间接导致元素稳态紊乱，如铁稳态。维持细胞和全身铁代谢的协调至关重要。否则，铁代谢紊乱会导致细胞毒性，并增加包括癌症在内的各种疾病的风险。因此，迫切需要研究环境污染物对铁稳态的影响。在这篇综述中，我们总结了关于环境污染物，包括持久性有机污染物（POPs）、重金属和农药，对铁稳态的直接或间接影响以及相关不良健康问题的现有研究结果。鉴于仍有未解决的问题，有必要做出更多努力来研究环境污染物对铁稳态的破坏作用及其导致的毒性。
