Post Robert M, Altshuler Lori, Kupka Ralph, McElroy Susan L, Frye Mark A, Rowe Michael, Grunze Heinz, Suppes Trisha, Keck Paul E, Leverich Gabriele S, Nolen Willem A
From the Bipolar Collaborative Network, Bethesda, MD (RMP, MR, GSL); Dept. of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC (RMP); Dept. of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA (LA); Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA (LA); Dept. of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands (RK); Lindner Center of HOPE, Mason, OH (SLM, PEK); Biological Psychiatry Program, University of Cincinnati Medical College, Cincinnati, OH (SLM); Dept. of Psychiatry, Mayo Clinic, Rochester, MN (MAF); Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom (HG); Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA (TS); VA Palo Alto Health Care System, Palo Alto, CA (TS); Dept. of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH (PEK); and University Medical Center, University of Groningen, Groningen, the Netherlands (WAN).
J Neuropsychiatry Clin Neurosci. 2015 Fall;27(4):304-10. doi: 10.1176/appi.neuropsych.14080204. Epub 2015 Aug 10.
The authors assessed how family history loading affected the course of illness in patients from the United States. A total of 676 outpatients with bipolar disorder from the United States rated their illness and provided a parental and grandparental history of mood disorder, substance abuse, and other clinical conditions. A positive family history for each illness was associated with almost all of the seven poor prognosis factors established in the study (abuse in childhood, early onset, anxiety and substance abuse comorbidity, rapid cycling, multiple episodes, and worsening of severity or frequency of episodes). Family history for psychiatric difficulties in parents and grandparents was associated with a more complex and difficult course of bipolar illness.
作者评估了家族病史负荷如何影响来自美国的患者的疾病进程。共有676名来自美国的双相情感障碍门诊患者对他们的病情进行了评分，并提供了父母和祖父母的情绪障碍、药物滥用及其他临床状况的病史。每种疾病的阳性家族史几乎与该研究确定的所有七个不良预后因素相关（童年期受虐、早发、焦虑与药物滥用共病、快速循环、多次发作以及发作严重程度或频率恶化）。父母和祖父母有精神疾病困难的家族史与双相情感障碍更复杂、更艰难的病程相关。
