Toptas Mehmet, Akkoc İbrahim, Savas Yildiray, Uzman Sinan, Toptas Yasar, Can Mehmet Mustafa
aHaseki Research and Education Hospital, Anesthesiology Clinic bHaseki Research and Education Hospital, Radiology Clinic İstanbul cSakarya Research and Education Hospital, Anesthesiology Clinic, Sakarya dHaseki Research and Education Hospital, Cardiology Clinic, İstanbul, Turkey.
Blood Coagul Fibrinolysis. 2016 Mar;27(2):127-30. doi: 10.1097/MBC.0000000000000372.
Acute mesenteric ischaemia (AMI) is an emergency condition that requires urgent diagnosis. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have been studied as inflammatory biomarkers in atherosclerosis, but data regarding AMI are lacking. The study population included patients with AMI (n = 46) versus age and sex-matched healthy controls (n = 46). Computed multidetector tomographic angiography was performed to diagnose AMI. NLR and PLR were calculated using complete blood count. C-reactive protein (CRP) levels were also analyzed. Neutrophil levels and lymphocytes were significantly higher in patients with AMI than in the control individuals (P < 0.001 and P = 0.43, respectively). NLR levels were significantly higher in patients with AMI compared with that in the control individuals (P < 0.001). Platelet levels did not reach statistical significance between the groups (P = 0.709). However, patients with AMI had significantly higher PLR levels than the control group (P = 0.039). CRP levels on admission were higher in patients with AMI in comparison with control individuals. There was also a positive correlation between NLR and CRP (r = 0.548, P < 0.001), and between PLR and CRP (r = 0.528, P < 0.001). NLR level greater than 4.5, measured on admission, yielded an area under the curve value of 0.790 (95% confidence interval 0.681-0.799, sensitivity 77%, specificity 72%), and PLR level of greater than 157 yielded an area under the curve value of 0.604 (95% confidence interval 0.486-0.722, sensitivity 59%, specificity 65%). Patients with AMI had increased NLR, PLR, and CRP levels compared with controls. Increased NLR and PLR was an independent predictor of AMI.
急性肠系膜缺血（AMI）是一种需要紧急诊断的急症。中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）已作为动脉粥样硬化中的炎症生物标志物进行研究，但关于AMI的数据尚缺。研究人群包括AMI患者（n = 46）以及年龄和性别匹配的健康对照者（n = 46）。采用多排螺旋CT血管造影术诊断AMI。通过全血细胞计数计算NLR和PLR。同时分析C反应蛋白（CRP）水平。AMI患者的中性粒细胞水平和淋巴细胞水平显著高于对照个体（分别为P < 0.001和P = 0.43）。与对照个体相比，AMI患者的NLR水平显著更高（P < 0.001）。两组间血小板水平未达到统计学显著性（P = 0.709）。然而，AMI患者的PLR水平显著高于对照组（P = 0.039）。AMI患者入院时的CRP水平高于对照个体。NLR与CRP之间也存在正相关（r = 0.548，P < 0.001），PLR与CRP之间也存在正相关（r = 0.528，P < 0.001）。入院时测得的NLR水平大于4.5，曲线下面积值为0.790（95%置信区间0.681 - 0.799，敏感性77%，特异性72%），PLR水平大于157时曲线下面积值为0.604（95%置信区间0.486 - 0.722，敏感性59%，特异性65%）。与对照组相比，AMI患者的NLR、PLR和CRP水平升高。NLR和PLR升高是AMI的独立预测因素。
