Suppr超能文献

宫颈气管原发性小细胞癌:一例报告及文献复习

Primary small cell cancer of cervical trachea: a case report and literature review.

作者信息

Qiu Jun, Lin Wei, Zhou Min-Li, Zhou Shui-Hong, Wang Qin-Ying, Bao Yang-Yang

机构信息

Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China ; Now Working at Department of Otolaryngology, The People's Hospital of Zhejiang Province 310014, China.

Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China.

出版信息

Int J Clin Exp Pathol. 2015 Jun 1;8(6):7488-93. eCollection 2015.

Abstract

UNLABELLED

Primary small cell carcinoma of trachea is even more uncommon and only a few cases have been reported. Our search revealed only 90 cases in the English-language literatures.

CASE REPORT

we report a case of cervical tracheal small cell cancer. A 67-year-old male presented with over 2-month history of cough and dyspnea. CT and MRI revealed a 1.0 cm × 2.5 cm intraluminal, irregular soft tissue mass in the upper trachea, approximately 2.5 cm below the glottis. A bronchoscopic examination disclosed a large tumor in the cervical trachea and the lesion occupied more than 60% of the tracheal lumen. Cytological examination suggested some poorly differentiated carcinoma cells. The patient received concurrent chemoradiotherapy and did not perform surgery. One week after CCR, the patient occurred difficulty in breath and tracheal stent was implanted. The symptom was improved markedly. Four days after implant of tracheal stent, the patient presented irritable cough and hemoptysis. The amount of bleeding was about 300 ml. The hemorrhage stopped by treatment of vasoconstrictor and fresh plasma. However, two days later, hemoptysis was continuing even if treatment of vasoconstrictor and fresh plasma. The patient and relatives waived the further therapies. The patient died of massive hemoptysis one week out of hospital.

CONCLUSIONS

The tracheal small cell cancer is rare. The optimal treatment is unclear. In general, the strategy is introduced concurrent chemoradiotherapy following as small cell lung cancer. In cervical trachea, we suggest that surgical resection should be performed followed by postoperative adjuvant therapy.

摘要

未标注

原发性气管小细胞癌更为罕见,仅有少数病例报道。我们的检索发现英文文献中仅有90例。

病例报告

我们报告一例颈段气管小细胞癌病例。一名67岁男性,有2个多月的咳嗽和呼吸困难病史。CT和MRI显示气管上段距声门约2.5 cm处有一个1.0 cm×2.5 cm腔内不规则软组织肿块。支气管镜检查发现颈段气管有一个大肿瘤,病变占据气管腔超过60%。细胞学检查提示有一些低分化癌细胞。患者接受同步放化疗,未进行手术。完全缓解(CCR)一周后,患者出现呼吸困难,植入气管支架。症状明显改善。气管支架植入4天后,患者出现刺激性咳嗽和咯血。出血量约300 ml。经血管收缩剂和新鲜血浆治疗后出血停止。然而,两天后,即使使用血管收缩剂和新鲜血浆治疗,咯血仍在继续。患者及其家属放弃进一步治疗。患者出院一周后死于大量咯血。

结论

气管小细胞癌罕见。最佳治疗方法尚不清楚。一般来说,治疗策略是按照小细胞肺癌进行同步放化疗。对于颈段气管,我们建议应先进行手术切除,然后进行术后辅助治疗。

相似文献

1
Primary small cell cancer of cervical trachea: a case report and literature review.
Int J Clin Exp Pathol. 2015 Jun 1;8(6):7488-93. eCollection 2015.
2
Malignant glomus tumor of trachea: a case report with literature review.
Asian Cardiovasc Thorac Ann. 2016 Jan;24(1):104-6. doi: 10.1177/0218492315608546. Epub 2015 Sep 28.
3
[Primary tracheal malignant glomus tumor with lung metastasis diagnosed by pathological analysis: a case report and literature review].
Zhonghua Jie He He Hu Xi Za Zhi. 2017 Sep 12;49(9):697-702. doi: 10.3760/cma.j.issn.1001-0939.2017.09.016.
6
Primary tracheal schwannoma: one case report and a literature review.
Eur Arch Otorhinolaryngol. 2005 Feb;262(2):157-60. doi: 10.1007/s00405-004-0778-0. Epub 2004 Apr 2.
8
[A very rare cause of haemoptysis - coexistence of primary oncocytic adenoma of trachea with bronchial carcinoma].
Dtsch Med Wochenschr. 2014 Jun;139(24):1295-8. doi: 10.1055/s-0034-1370103. Epub 2014 Jun 3.
9
Sarcomatoid carcinoma in the trachea: A case report and literature review.
Thorac Cancer. 2017 May;8(3):278-282. doi: 10.1111/1759-7714.12437. Epub 2017 Mar 30.
10
[Tracheal adenoid cystic carcinoma presenting as a thyroid tumor].
Kulak Burun Bogaz Ihtis Derg. 2006;16(5):224-6.

引用本文的文献

本文引用的文献

1
Extrapulmonary small cell carcinoma in head and neck.
J Laryngol Otol. 2015 Mar;129 Suppl 2:S83-5. doi: 10.1017/S002221511400245X.
2
Synchronous primary cancers of trachea and esophagus and ventricular tachycardia.
Chin J Cancer Res. 2014 Jun;26(3):345-50. doi: 10.3978/j.issn.1000-9604.2014.06.06.
3
Tracheal cancer: Role of radiation therapy.
Rep Pract Oncol Radiother. 2010 Oct 6;15(5):113-8. doi: 10.1016/j.rpor.2010.08.005. eCollection 2010.
4
Pathology of tracheal tumors.
Thorac Surg Clin. 2014 Feb;24(1):7-11. doi: 10.1016/j.thorsurg.2013.09.008.
5
Tracheal and airway neoplasms.
Semin Roentgenol. 2013 Oct;48(4):354-64. doi: 10.1053/j.ro.2013.03.018.
6
Management and prognosis of primary tracheal cancer: a national analysis.
Laryngoscope. 2014 Jan;124(1):145-50. doi: 10.1002/lary.24123. Epub 2013 Jul 19.
7
Clinical manifestation and management of primary malignant tumors of the cervical trachea.
Eur Arch Otorhinolaryngol. 2014 Feb;271(2):225-35. doi: 10.1007/s00405-013-2429-9. Epub 2013 Mar 20.
8
Small-cell cancer presenting as a tracheal polyp: a case report and review of the literature.
J Bronchology Interv Pulmonol. 2012 Apr;19(2):132-6. doi: 10.1097/LBR.0b013e31824dd182.
10
Carcinoid of the trachea in a young adult male responsive to chemo-radiation.
Indian J Otolaryngol Head Neck Surg. 2011 Jul;63(Suppl 1):13-5. doi: 10.1007/s12070-011-0171-4. Epub 2011 Apr 11.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验