Ramachandran Sudarshan, Strange Richard C, Jones Peter W, Kalra Seema, Nayak Devaki, Hawkins Clive P
Keele Multiple Sclerosis Research Group, Department of Neurology, University Hospital of North Staffordshire, Stoke-on-Trent, ST4 7LN Staffordshire, England, United Kingdom; Department of Biochemistry, Good Hope Hospital, Heart of England Foundation Trust, Sutton Coldfield B75 7RR, England, United Kingdom.
Keele Multiple Sclerosis Research Group, Department of Neurology, University Hospital of North Staffordshire, Stoke-on-Trent, ST4 7LN Staffordshire, England, United Kingdom; Institute for Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, Stoke-on-Trent ST4 7QB, England, United Kingdom.
Mult Scler Relat Disord. 2014 Sep;3(5):593-9. doi: 10.1016/j.msard.2014.06.002. Epub 2014 Jun 24.
While many factors have been examined, male gender and older age at multiple sclerosis onset are among few variables consistently associated with increased disability. Interestingly, the association between onset age and disability may not be linear with some data suggesting a faster rate of accumulation of disability in patients aged more than 30 years at onset.
Explore the relationship between onset age and disability.
We studied 500 MS patients grouped by cut-offs in onset age. Disability was assessed using Multiple Sclerosis Severity Scale (MSSS) and, a model based on time to reach an Extended Disability Severity Score (EDSS) (progression model). Data were analyzed using linear and logistic regression.
The association between disability (assessed by both MSSS and the progression model) and onset age was different in patients whose MS onset occurred after an age band of 30-35 years. Before this age range, changing age was not associated with changes in disability while during and after this age range, disability was increased.
We found a significant change in the relationship between disability and onset age after about 31 years supporting the idea that while onset age does not define a sharp cut-off, it can help define subgroups of patients with differing rates of accumulation of disability.
虽然已经对许多因素进行了研究，但男性以及多发性硬化症发病时年龄较大是少数几个一直与残疾增加相关的变量。有趣的是，发病年龄与残疾之间的关联可能不是线性的，一些数据表明，发病时年龄超过30岁的患者残疾累积速度更快。
探讨发病年龄与残疾之间的关系。
我们研究了500例按发病年龄切点分组的多发性硬化症患者。使用多发性硬化症严重程度量表（MSSS）以及基于达到扩展残疾严重程度评分（EDSS）的时间的模型（进展模型）来评估残疾情况。使用线性和逻辑回归分析数据。
在发病年龄在30 - 35岁年龄组之后发病的患者中，残疾（通过MSSS和进展模型评估）与发病年龄之间的关联有所不同。在这个年龄范围之前，年龄变化与残疾变化无关，而在这个年龄范围期间及之后，残疾增加。
我们发现大约31岁之后残疾与发病年龄之间的关系发生了显著变化，这支持了这样一种观点，即虽然发病年龄没有明确的界限，但它有助于定义残疾累积率不同的患者亚组。
