Cierny D, Lehotsky J, Hanysova S, Michalik J, Kantorova E, Sivak S, Kurca E, Dobrota D, Jesenska L
Bratisl Lek Listy. 2017;118(6):374-377. doi: 10.4149/BLL_2017_071.
The causes of the individual differences in the rate of disability progression in multiple sclerosis (MS) are still not completely clear. According to the long-term prognosis of MS patients, the search for new valuable prognostic markers of "benign" or "malign" MS is necessary.
Our aim was to assess the possible association of MS onset age with the disease disability progression rate in Slovak patients with MS.
By the unique pattern of evaluation of disability progression rate using Multiple Sclerosis Severity Score (MSSS), each of 270 MS patients was defined as slow-progressing, mid-rate progressing or rapidly progressing.
We found a significant differences in the age at onset between MS patients with different rate of disability progression (p(K-W)<0,00005). The faster was a disability progression assessed by MSSS score, the higher was the MS onset age.
We showed for the first time in Central European Slovak population that MS onset age is an early marker that is in the positive correlation with disease disability progression rate, evaluated by MSSS score. We conclude that relapsing-remitting MS patients older at clinical onset have a higher risk of unfavorable prognosis (Tab. 2, Fig. 1, Ref. 21).
多发性硬化症（MS）患者残疾进展速度存在个体差异的原因仍不完全清楚。根据MS患者的长期预后，有必要寻找新的有价值的“良性”或“恶性”MS预后标志物。
我们的目的是评估斯洛伐克MS患者的发病年龄与疾病残疾进展速度之间可能存在的关联。
通过使用多发性硬化症严重程度评分（MSSS）评估残疾进展速度的独特模式，将270例MS患者中的每一例定义为进展缓慢、中等速度进展或快速进展。
我们发现不同残疾进展速度的MS患者发病年龄存在显著差异（p（K-W）<0.00005）。MSSS评分评估的残疾进展越快，MS发病年龄越高。
我们首次在中欧斯洛伐克人群中表明，MS发病年龄是一个早期标志物，与通过MSSS评分评估的疾病残疾进展速度呈正相关。我们得出结论，临床发病时年龄较大的复发缓解型MS患者预后不良的风险较高（表2，图1，参考文献21）。
