化疗诱导性周围神经病的信息基因网络。
Informative gene network for chemotherapy-induced peripheral neuropathy.
机构信息
Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
出版信息
BioData Min. 2015 Aug 12;8:24. doi: 10.1186/s13040-015-0058-0. eCollection 2015.
BACKGROUND
Host genetic variability has been implicated in chemotherapy-induced peripheral neuropathy (CIPN). A dose-limiting toxicity for chemotherapy agents, CIPN is also a debilitating condition that may progress to chronic neuropathic pain. We utilized a bioinformatics approach, which captures the complexity of intracellular and intercellular interactions, to identify genes for CIPN.
METHODS
Using genes pooled from the literature as a starting point, we used Ingenuity Pathway Analysis (IPA) to generate gene networks for CIPN.
RESULTS
We performed IPA core analysis for genes associated with platinum-, taxane- and platinum-taxane-induced neuropathy. We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.
CONCLUSION
Neurotoxicity is common in cancer patients treated with platinum compounds and anti-microtubule agents and CIPN is one of the debilitating sequela. The bioinformatic approach helped identify genes associated with CIPN in cancer patients.
背景
宿主遗传变异性与化疗引起的周围神经病变（CIPN）有关。CIPN 是化疗药物的一种剂量限制毒性，也是一种使人虚弱的疾病，可能发展为慢性神经性疼痛。我们利用一种生物信息学方法，该方法可以捕捉细胞内和细胞间相互作用的复杂性，来确定与 CIPN 相关的基因。
方法
我们使用文献中汇集的基因作为起点，使用 Ingenuity Pathway Analysis（IPA）生成 CIPN 的基因网络。
结果
我们对与铂类、紫杉烷类和铂类-紫杉烷类诱导的神经病相关的基因进行了 IPA 核心分析。我们发现，在铂类诱导的神经病中，IL6、TNF、CXCL8、IL1B 和 ERK1/2 是连接数最多的基因，而在联合紫杉烷-铂类诱导的神经病中，TP53、MYC、PARP1、P38 MAPK 和 TNF 是连接数最多的基因。
结论
接受铂化合物和抗微管药物治疗的癌症患者中常见神经毒性，CIPN 是其使人虚弱的后遗症之一。生物信息学方法有助于确定与癌症患者 CIPN 相关的基因。
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