肾上腺切除术和糖皮质激素治疗对泌乳期大鼠乳腺和脂肪组织中酶活性的影响。

Effects of adrenalectomy and glucocorticoid therapy on enzyme activities in mammary and adipose tissues from lactating rats.

作者信息

Plucinski T, Baldwin R L

出版信息

J Dairy Sci. 1976 Jan;59(1):157-60. doi: 10.3168/jds.S0022-0302(76)84170-7.

Abstract

Several mammary and adipose enzymes were measured in normal, adrenal-ectomized, adrenalectomized cortisol-treated, and intake-restricted lactating rats. Acetyl-CoA carboxylase, lipoprotein lipase, and triglyceride synthetase complex activities in mammary tissue were unchanged by intake restriction, decreased by adrenalectomy, and increased by glucocorticoid-replacement therapy. Malic dehydrogenase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and lipoprotein lipase activities in adipose were unchanged after adrenalectomy.

摘要

在正常、肾上腺切除、肾上腺切除后接受皮质醇治疗以及摄入受限的泌乳大鼠中，检测了几种乳腺和脂肪酶。乳腺组织中的乙酰辅酶A羧化酶、脂蛋白脂肪酶和甘油三酯合成酶复合物活性不受摄入限制的影响，肾上腺切除使其降低，而糖皮质激素替代疗法使其升高。肾上腺切除后，脂肪中的苹果酸脱氢酶、葡萄糖-6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶和脂蛋白脂肪酶活性未发生变化。