低反应水平激光疗法治疗间充质基质细胞疗法。
Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies.
机构信息
Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
出版信息
Stem Cells Int. 2015;2015:974864. doi: 10.1155/2015/974864. Epub 2015 Jul 26.
Abstract
Low reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty years, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term LLLT has become widely recognized in the field of regenerative medicine. In this review, we will describe the mechanisms of action of LLLT at a cellular level and introduce the application to mesenchymal stem cells and mesenchymal stromal cells (MSCs) therapies. Finally, our recent research results that LLLT enhanced the MSCs differentiation to osteoblast will also be described.
摘要
低强度激光疗法（LLLT）主要通过使用低功率激光来激活细胞内或细胞外的发色团，并启动细胞信号转导。在过去的四十年中，人们已经意识到激光疗法具有改善伤口愈合和减轻疼痛和炎症的潜力。近年来，LLLT 一词在再生医学领域得到了广泛认可。在这篇综述中，我们将描述 LLLT 在细胞水平上的作用机制，并介绍其在间充质干细胞和间充质基质细胞（MSCs）治疗中的应用。最后，我们还将描述 LLLT 增强 MSCs 向成骨细胞分化的最新研究结果。
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