细粒度骨整合涂层可改善聚醚醚酮在异位绵羊模型中的生物相容性。
Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model.
作者信息
Meers Caroline M F, Verleye Gino B M, Smeets Dirk, Van Hauwermeiren Hadewych Y R, Loeckx Dirk, Willems Karel, Siau Vincent G M G G B, Lauweryns Philippe J M E
机构信息
Medanex Clinic, Diest, Belgium.
Social Sciences Department, Ghent University, Ghent, Belgium.
出版信息
Int J Spine Surg. 2015 Jul 17;9:35. doi: 10.14444/2035. eCollection 2015.
BACKGROUND AND AIM
Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK implants to bone tissue proceeds slowly because of their relatively low biocompatibility. The aim of the study is to evaluate the effect of titanium and CaP coating on the adhesion of bone tissue.
MATERIAL AND METHODS
Six adult sheep (body weight 57.6 ± 3.9 kg) were included in this study. Three different types of cylindrical dowels (12 mm length x 8 mm diameter) were implanted in long bones (tibia and femur): PEEK dowels without coating (the control group), and PEEK dowels with a nanocoating of calcium phosphate (CaP group) or titanium (titanium group). Animals were sacrificed after 6, 12 and 26 weeks. Dowels were explanted for micro CT and histology.
RESULTS
Bone implant contact (BIC) ratio was significantly higher in the titanium versus control groups in the 6 to 12 weeks period (p = 0.03). The ratio between bone volume and tissue volume (BV/TV) was significantly higher in titanium versus control in the 6 to 12 weeks period (p = 0.02). A significant correlation between BIC and BV/TV was seen (r = 0.85, p < 0.05).
CONCLUSION
Coating of PEEK dowels with a nanocoating of titanium has beneficial effects on adhesion of bone tissue.
背景与目的
聚醚醚酮（PEEK）材料已成功应用于骨科手术，尤其是脊柱手术。PEEK是射线可透过的，且在弹性方面与骨相当。然而，PEEK是惰性的，由于其生物相容性相对较低，PEEK植入物与骨组织的粘附进展缓慢。本研究的目的是评估钛和磷酸钙（CaP）涂层对骨组织粘附的影响。
材料与方法
本研究纳入6只成年绵羊（体重57.6±3.9千克）。将三种不同类型的圆柱形销钉（长度12毫米×直径8毫米）植入长骨（胫骨和股骨）：未涂层的PEEK销钉（对照组），以及涂有磷酸钙纳米涂层的PEEK销钉（CaP组）或钛涂层的PEEK销钉（钛组）。在6周、12周和26周后处死动物。取出销钉进行显微CT和组织学检查。
结果
在6至12周期间，钛组的骨植入物接触（BIC）率显著高于对照组（p = 0.03）。在6至12周期间，钛组的骨体积与组织体积之比（BV/TV）显著高于对照组（p = 0.02）。观察到BIC与BV/TV之间存在显著相关性（r = 0.85，p < 0.05）。
结论
用钛纳米涂层对PEEK销钉进行涂层对骨组织的粘附具有有益作用。
Zotero 插件