Walsh William R, Bertollo Nicky, Christou Chrisopher, Schaffner Dominik, Mobbs Ralph J
Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, The University of New South Wales, Prince of Wales Hospital, Level 1 Clinical Science Building, Avoca Street, Randwick, Sydney, Australia, 2031.
Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, The University of New South Wales, Prince of Wales Hospital, Level 1 Clinical Science Building, Avoca Street, Randwick, Sydney, Australia, 2031.
Spine J. 2015 May 1;15(5):1041-9. doi: 10.1016/j.spinee.2014.12.018. Epub 2014 Dec 24.
Rapid and stable fixation at the bone-implant interface would be regarded as one of the primary goals to achieve clinical efficacy, regardless of the surgical site. Although mechanical and physical properties of polyetheretherketone (PEEK) provide advantages for implant devices, the hydrophobic nature and the lack of direct bone contact remains a limitation.
To examine the effects of a plasma-sprayed titanium coated PEEK on the mechanical and histologic properties at the bone-implant interface.
A preclinical laboratory study.
Polyetheretherketone and plasma-sprayed titanium coated PEEK implants (Ti-bond; Spinal Elements, Carlsbad, CA, USA) were placed in a line-to-line manner in cortical bone and in a press-fit manner in cancellous bone of adult sheep using an established ovine model. Shear strength was assessed in the cortical sites at 4 and 12 weeks, whereas histology was performed in cortical and cancellous sites at both time points.
The titanium coating dramatically improved the shear strength at the bone-implant interface at 4 weeks and continued to improve with time compared with PEEK. Direct bone ongrowth in cancellous and cortical sites can be achieved using a plasma-sprayed titanium coating on PEEK.
Direct bone to implant bonding can be achieved on PEEK in spite of its hydrophobic nature using a plasma-sprayed titanium coating. The plasma-sprayed titanium coating improved mechanical properties in the cortical sites and the histology in cortical and cancellous sites.
无论手术部位如何，在骨-植入物界面实现快速稳定的固定都被视为实现临床疗效的主要目标之一。尽管聚醚醚酮（PEEK）的机械和物理性能为植入装置提供了优势，但其疏水性和缺乏与骨的直接接触仍然是一个限制因素。
研究等离子喷涂钛涂层PEEK对骨-植入物界面的机械和组织学性能的影响。
临床前实验室研究。
使用成熟的绵羊模型，将聚醚醚酮和等离子喷涂钛涂层PEEK植入物（Ti-bond；Spinal Elements，美国加利福尼亚州卡尔斯巴德）以对线方式放置在成年绵羊的皮质骨中，并以压配方式放置在松质骨中。在4周和12周时评估皮质部位的剪切强度，而在两个时间点对皮质和松质部位进行组织学检查。
与PEEK相比，钛涂层在4周时显著提高了骨-植入物界面的剪切强度，并且随着时间的推移持续改善。在PEEK上使用等离子喷涂钛涂层可在松质和皮质部位实现骨的直接生长。
尽管PEEK具有疏水性，但使用等离子喷涂钛涂层仍可在PEEK上实现骨与植入物的直接结合。等离子喷涂钛涂层改善了皮质部位的机械性能以及皮质和松质部位的组织学表现。
