Klen Jasna, Goričar Katja, Janež Andrej, Dolžan Vita
General Hospital Trbovlje, Rudarska cesta 9, SI-1420 Trbovlje, Slovenia.
Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia.
J Diabetes Res. 2015;2015:616747. doi: 10.1155/2015/616747. Epub 2015 Jul 27.
It is generally accepted that poor glycemic control, arterial hypertension and/or hyperlipidemia, and the associated oxidative stress may contribute to the development of macro- and microvascular complications in type 2 diabetes (T2D). Such metabolic damage signals may activate inflammasome and trigger chronic inflammation. We investigated common polymorphisms in inflammasome coding genes and the risk for macro- and microvascular complications in T2D.
In total 181 clinically well-characterised T2D patients were genotyped for NLRP3 rs35829419 and CARD8 rs2043211. Risk for diabetic complications was assessed using logistic regression.
Patients with median duration of T2D 11 (6-17) years had relatively well controlled blood glucose and lipid levels and blood pressure on the prescribed treatment regimen. Duration of T2D and plasma cholesterol levels were the most important clinical risk factors for macrovascular complications (P = 0.007 and P = 0.031). NLRP3 rs35829419 was associated with increased risk for macrovascular complications (P = 0.004), with myocardial infarction in particular (P = 0.052). No association was observed between CARD8 polymorphism and any of T2D complications.
Our preliminary data suggest the role of NLRP3 polymorphism in diabetic macrovascular complications, especially in myocardial infarction.
一般认为，血糖控制不佳、动脉高血压和/或高脂血症以及相关的氧化应激可能导致2型糖尿病（T2D）大血管和微血管并发症的发生。这种代谢损伤信号可能激活炎性小体并引发慢性炎症。我们研究了炎性小体编码基因的常见多态性与T2D大血管和微血管并发症的风险。
对总共181例临床特征明确的T2D患者进行NLRP3 rs35829419和CARD8 rs2043211基因分型。使用逻辑回归评估糖尿病并发症的风险。
T2D病程中位数为11（6 - 17）年的患者在规定治疗方案下血糖、血脂水平和血压控制相对良好。T2D病程和血浆胆固醇水平是大血管并发症最重要的临床风险因素（P = 0.007和P = 0.031）。NLRP3 rs35829419与大血管并发症风险增加相关（P = 0.004），尤其是心肌梗死（P = 0.052）。未观察到CARD8多态性与任何T2D并发症之间存在关联。
我们的初步数据表明NLRP3多态性在糖尿病大血管并发症中起作用，尤其是在心肌梗死中。
