Alati R, Betts K S, Williams G M, Najman J M, Zalbahar N, Mamun A
School of Public Health and Centre for Youth Substance Abuse Research, University of Queensland, Brisbane, Queensland, Australia.
School of Population Health, The University of Queensland, Brisbane, Queensland, Australia.
Int J Obes (Lond). 2016 Jan;40(1):176-80. doi: 10.1038/ijo.2015.153. Epub 2015 Aug 17.
BACKGROUND/OBJECTIVES: Increases in obesity in young adults over recent decades are shown by national survey data but have yet to be replicated using prospective data. We aim to quantify the increase in obesity and overweight over two generations of young adult women using prospective measures of body mass index (BMI).
SUBJECTS/METHODS: Data are from the Mater University Study of Pregnancy (MUSP), a prospective pre-birth cohort study started in 1981 in Brisbane, Australia. Analyses were restricted to 992 mother-daughter dyads who were at similar ages at the time they were assessed and for whom measures of BMI were available. We also conducted an additional analysis to test whether there was a similar increase amongst father-son dyads. We used multinomial logistic regression for clustered data to compare the same prospective measures of BMI categories between mother and daughters.
Controlling for a number of sociodemographic and lifestyle factors in the female sample, daughters had 5.04 (3.03, 8.85) times the odds of being obese and 2.54 (1.86, 3.54) times the odds of being overweight compared with their mothers. A large increase in obesity was also observed in the male sample.
Using a longitudinal design to partly account for familial confounding of obesity risk factors, this study confirms a large and concerning increases in obesity rates over two generations of young adults and suggests increases in obesity over the past 20 years may be greater than previously anticipated.
背景/目的:全国调查数据显示,近几十年来年轻成年人肥胖率有所上升,但尚未通过前瞻性数据得到证实。我们旨在使用体重指数(BMI)的前瞻性测量方法,量化两代年轻成年女性肥胖和超重情况的增加。
对象/方法:数据来自莫特大学孕期研究(MUSP),这是一项于1981年在澳大利亚布里斯班启动的前瞻性产前队列研究。分析仅限于992对母女二元组,她们在接受评估时年龄相近且有BMI测量值。我们还进行了一项额外分析,以检验父子二元组中是否有类似的增加情况。我们使用聚类数据的多项逻辑回归来比较母亲和女儿之间BMI类别相同的前瞻性测量值。
在女性样本中控制了一些社会人口学和生活方式因素后,与母亲相比,女儿肥胖的几率是母亲的5.04(3.03,8.85)倍,超重的几率是母亲的2.54(1.86,3.54)倍。在男性样本中也观察到肥胖率大幅上升。
本研究采用纵向设计以部分解释肥胖风险因素的家族混杂情况,证实了两代年轻成年人肥胖率大幅且令人担忧的上升,并表明过去20年肥胖率的上升可能比之前预期的更大。