[The functional organization of autoregulation of local cerebral blood flow in spontaneously hypertensive rats in ontogeny].

The autoregulation of local cerebral blood flow in the cortex of 5, 8-10-, 16-20- and 46-50-week old spontaneously hypertensive rats involved responses to raising or lowering systemic blood pressure, reflecting an interaction among myogenic, neurogenic and metabolic mechanisms. In formation and stabilization of spontaneous hypertension, a reorganization of the autoregulation of local cerebral blood flow depending upon the level of blood pressure, occurred. The myogenic component seems to play a major role in the mechanisms of maintenance of constant blood supply in micro-areas of the brain in acute shifts of the blood pressure in spontaneously hypertensive rats.