Wang Yujie, Miocinovic Svjetlana, Greenberg Benjamin M
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX.
Neurologist. 2015 Aug;20(2):33-4. doi: 10.1097/NRL.0000000000000043.
Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by monophasic or recurrent attacks of optic neuritis (ON) and transverse myelitis. NMO spectrum disorders include patients who are seropositive for NMO-IgG antibody and have experienced at least 1 demyelinating attack. NMO has been associated with other autoimmune conditions. We describe a patient diagnosed with autoimmune hemolytic anemia and marginal zone lymphoma, who later developed NMO-IgG seropositive ON. The coexistence of multiple immunologic abnormalities in this patient points to a generalized dysfunction of the humoral immune system. History of autoimmunity should alert the clinician to the possibility of NMO spectrum disorder in a patient presenting with isolated ON.
视神经脊髓炎（NMO）是一种炎症性脱髓鞘疾病，其特征为单相或复发性视神经炎（ON）和横贯性脊髓炎发作。NMO谱系障碍包括NMO-IgG抗体血清学阳性且经历过至少1次脱髓鞘发作的患者。NMO与其他自身免疫性疾病有关。我们描述了一名被诊断为自身免疫性溶血性贫血和边缘区淋巴瘤的患者，该患者后来发展为NMO-IgG血清学阳性的视神经炎。该患者多种免疫异常的共存提示体液免疫系统存在广泛功能障碍。自身免疫病史应提醒临床医生，对于表现为孤立性视神经炎的患者，要警惕NMO谱系障碍的可能性。
