Everly Matthew J
Clin Transpl. 2014:125-9.
In the last few years, there have been studies published on serial testing and longitudinal analysis of anti-human leukocyte antigen (anti-HLA) antibodies. The focus of these studies was to determine specific characteristics of the impact of donor specific anti-HLA antibodies (DSA) in organ transplant dysfunction. These publications have led to an increasing concern about DSA and a growing effort to better understand DSA and to develop treatment for patients with DSA. In 2014, several reports were published that either confirm or expand upon both the understanding of the humoral theory and the clinical applications of DSA testing. This review delves into these publications and reports how their findings fit into the humoral theory of transplant.
在过去几年中，已经发表了关于抗人类白细胞抗原（抗HLA）抗体的系列检测和纵向分析的研究。这些研究的重点是确定供体特异性抗HLA抗体（DSA）对器官移植功能障碍影响的具体特征。这些出版物引发了人们对DSA日益增加的关注，以及为更好地理解DSA并为DSA患者开发治疗方法而做出的越来越多的努力。2014年，发表了几篇报告，这些报告要么证实了对体液理论的理解，要么扩展了DSA检测的临床应用。这篇综述深入探讨了这些出版物，并报告了它们的研究结果如何与移植的体液理论相契合。
