Yang Qiong, Ye Zaiyuan, Zhang Qi, Zhao Zhongsheng, Yuan Hongjun
Wenzhou Medical University, Wenzhou, China.
Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Tumour Biol. 2016 Jan;37(1):1189-95. doi: 10.1007/s13277-015-3894-0. Epub 2015 Aug 18.
Altered expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) was associated with human carcinogenesis and progression. This study assessed eIF5A-2 expression in gastric cancer tissues for association with clinicopathological parameters and survival of patients. A total of 436 gastric cancer tissues and 92 normal mucosal blocks were collected for construction of tissue microarrays and immunohistochemical assessment of eIF5A-2 expression. The data were statistically analyzed for association with clinicopathological factors and survival of patients. Immunohistochemical data showed that eIF5A-2 protein was highly expressed in gastric cancer tissues (p < 0.001). Upregulated expression of eIF5A-2 protein was associated with tumor Lauren classification, size, location, invasion, TNM stages, and lymph node and distant metastases. The 3- and 5-year cumulative survival rates of these 436 patients were 88.5 and 58.1 %, respectively. In contrast, the mean survival time of patients with increased tumor eIF5A-2 was 30.22 ± 1.23 vs. 51.29 ± 0.86 months for those with low tumor eIF5A-2 (p < 0.001). Multivariate analysis showed that eIF5A-2 expression and related tumor parameters were independent indicators of overall survival in gastric cancer patients. In conclusion, the current study indicates that overexpression of eIF5A-2 protein was associated with poor overall survival of gastric cancer patients.
真核生物翻译起始因子5A-2（eIF5A-2）表达的改变与人类癌症的发生和进展相关。本研究评估了胃癌组织中eIF5A-2的表达情况，以探讨其与临床病理参数及患者生存率的关系。共收集了436例胃癌组织和92例正常黏膜组织块，用于构建组织芯片并进行eIF5A-2表达的免疫组织化学评估。对数据进行统计学分析，以确定其与临床病理因素及患者生存率的关系。免疫组织化学数据显示，eIF5A-2蛋白在胃癌组织中高表达（p＜0.001）。eIF5A-2蛋白表达上调与肿瘤的Lauren分类、大小、位置、浸润、TNM分期以及淋巴结和远处转移相关。这436例患者的3年和5年累积生存率分别为88.5%和58.1%。相比之下，肿瘤eIF5A-2升高患者的平均生存时间为30.22±1.23个月，而肿瘤eIF5A-2低表达患者为51.29±0.86个月（p＜0.001）。多因素分析表明，eIF5A-2表达及相关肿瘤参数是胃癌患者总生存的独立指标。总之，本研究表明eIF5A-2蛋白过表达与胃癌患者较差的总生存相关。
