Pant R, Ramana D
Indian J Biochem Biophys. 1989 Aug;26(4):268-72.
Administration of malathion to the developing Philosamia ricini larvae induces accumulation of acetylcholine, marked inhibition of acetylcholinesterase activity, depletion of all nutrients, heavy weight loss and high mortality. Pre-treatment of the larvae with acetylcholine via feed, reduces malathion toxicity and conversely, feeding of acetylcholine to malathion-treated larvae reverses the toxic effects. Resumption of normal control feed to malathion-treated insects results in higher mortality than in insects fed acetylcholine after exposure to malathion. This emphasizes the therapeutic action of acetylcholine. Feeding of a mixture of equal quantities of malathion and acetylcholine recorded significantly lower mortality among insects in comparison to those fed malathion alone. This further supports the protective action of acetylcholine. Reversal of malathion toxicity and the protective action of acetylcholine have been attributed to the mediation of choline, an essential insect vitamin that gets released as a catabolic product of acetylcholine.
对发育中的蓖麻蚕幼虫施用马拉硫磷会导致乙酰胆碱积累、乙酰胆碱酯酶活性受到显著抑制、所有营养物质耗竭、体重严重减轻和高死亡率。通过饲料对幼虫进行乙酰胆碱预处理可降低马拉硫磷的毒性，相反，给经马拉硫磷处理的幼虫喂食乙酰胆碱可逆转毒性作用。给经马拉硫磷处理的昆虫恢复正常对照饲料导致的死亡率高于暴露于马拉硫磷后喂食乙酰胆碱的昆虫。这强调了乙酰胆碱的治疗作用。与仅喂食马拉硫磷的昆虫相比，喂食等量马拉硫磷和乙酰胆碱混合物的昆虫死亡率显著降低。这进一步支持了乙酰胆碱的保护作用。马拉硫磷毒性的逆转和乙酰胆碱的保护作用归因于胆碱的介导，胆碱是一种必需的昆虫维生素，作为乙酰胆碱的分解代谢产物释放出来。
