抗菌和益生菌治疗后阴道微生物群的变化。
Changes in vaginal microbiota following antimicrobial and probiotic therapy.
作者信息
Macklaim Jean M, Clemente Jose C, Knight Rob, Gloor Gregory B, Reid Gregor
机构信息
Canadian Research & Development Centre for Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Department of Biochemistry, University of Western Ontario, London, Ontario, Canada.
出版信息
Microb Ecol Health Dis. 2015 Aug 14;26:27799. doi: 10.3402/mehd.v26.27799. eCollection 2015.
BACKGROUND
The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious.
OBJECTIVE AND DESIGN
We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions.
RESULTS
While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged by therapy, Gardnerella vaginalis, Prevotella, Atopobium, Sneathia, and Megasphaera dominated the vagina of women with bacterial vaginosis (BV), and treatment with tinidazole plus Lactobacillus reuteri RC-14+L. rhamnosus GR-1 resulted in an increased relative abundance of indigenous L. iners or L. crispatus.
CONCLUSIONS
The ability to restore homeostasis provides a rationale for conjoint use of probiotics with antibiotic treatment of BV.
背景
已知阴道微生物群的组成对健康很重要。当发生感染时，抗菌治疗往往效果不佳。
目的与设计
我们使用16S rRNA基因测序来表征口服抗菌药物和益生菌干预后细菌微生物群的变化。
结果
虽然外阴阴道念珠菌病女性的阴道细菌谱与健康女性一样以乳酸杆菌为主，且不受治疗影响，但阴道加德纳菌、普雷沃菌、阿托波菌、斯内特菌和巨球形菌在细菌性阴道病（BV）女性的阴道中占主导地位，而替硝唑加罗伊氏乳杆菌RC-14+鼠李糖乳杆菌GR-1治疗导致本土惰性乳杆菌或卷曲乳杆菌的相对丰度增加。
结论
恢复内环境稳定的能力为益生菌与BV抗生素治疗联合使用提供了理论依据。
Zotero 插件