原发性免疫缺陷病最新进展：第二部分。与黏膜皮肤念珠菌病及非感染性皮肤表现相关的综合征
Primary immunodeficiency update: Part II. Syndromes associated with mucocutaneous candidiasis and noninfectious cutaneous manifestations.
作者信息
Pichard Dominique C, Freeman Alexandra F, Cowen Edward W
机构信息
National Institutes of Health, National Cancer Institute, Bethesda, Maryland.
National Institute of Allergy and Infectious Disease, Bethesda, Maryland.
出版信息
J Am Acad Dermatol. 2015 Sep;73(3):367-81; quiz 381-2. doi: 10.1016/j.jaad.2015.01.055.
Abstract
Several primary immunodeficiencies (PIDs) have recently been described that confer an elevated risk of fungal infections and noninfectious cutaneous manifestations. In addition, immunologic advances have provided new insights into our understanding of the pathophysiology of fungal infections in established PIDs. We reviewed PIDs that present with an eczematous dermatitis in part I. In part II of this continuing medical education article we discuss updates on PIDs associated with fungal infections, their biologic basis in PIDs, and noninfectious cutaneous manifestations.
摘要
最近已经描述了几种原发性免疫缺陷病（PID），它们会增加真菌感染和非感染性皮肤表现的风险。此外，免疫学进展为我们理解已确诊的PID中真菌感染的病理生理学提供了新的见解。在本文的第一部分，我们回顾了表现为湿疹性皮炎的PID。在这篇继续医学教育文章的第二部分，我们讨论与真菌感染相关的PID的最新情况、它们在PID中的生物学基础以及非感染性皮肤表现。
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