白细胞介素-1可引发大鼠心房心肌的电活动异常。
IL-1 provokes electrical abnormalities in rat atrial myocardium.
作者信息
Mitrokhin V M, Mladenov M I, Kamkin A G
机构信息
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, Macedonia.
出版信息
Int Immunopharmacol. 2015 Sep;28(1):780-4. doi: 10.1016/j.intimp.2015.08.006. Epub 2015 Aug 15.
Using a micro-electrode technique we studied the effects of interleukin 1α and interleukin 1β on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching. Perfusion with interleukin 1α increased the duration of the action potential at the level of 90% re-polarization. Stretch induced tachy-arrhythmia in the presence of interleukin 1α is mainly regulated via stretch increased nitric oxide production, while the ionotropic effect of the interleukin-1α during stretching is not pronounced. The perfusion with interleukin 1β did not change the values of the duration of the action potentials at the levels of 25, 50 and 90% repolarization. The interleukin lβ caused an appearance of extra-systolic patterns which turned into normal rhythm, alternating with periods of normal activity. The total intracellular nitric oxide level induced by both interleukin 1β and stretching is balanced by interleukin-1β induced cation influx.
我们采用微电极技术，研究了白细胞介素1α和白细胞介素1β在正常条件下以及逐渐拉伸后对大鼠心房心肌生物电活动的影响。用白细胞介素1α灌注可增加动作电位在复极化90%水平时的持续时间。在存在白细胞介素1α的情况下，拉伸诱发的快速心律失常主要通过拉伸增加一氧化氮生成来调节，而拉伸过程中白细胞介素1α的离子otropic效应并不明显。用白细胞介素1β灌注在复极化25%、50%和90%水平时并未改变动作电位持续时间的值。白细胞介素1β导致出现期外收缩模式，其转变为正常节律，并与正常活动期交替出现。白细胞介素1β和拉伸诱导的细胞内总一氧化氮水平由白细胞介素1β诱导的阳离子内流平衡。
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