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Novel chemobiosynthetic approach for exclusive production of FK506.
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3
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Appl Environ Microbiol. 2011 Oct;77(19):6982-90. doi: 10.1128/AEM.05781-11. Epub 2011 Aug 5.
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A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.
Appl Microbiol Biotechnol. 2011 Sep;91(5):1389-97. doi: 10.1007/s00253-011-3348-6. Epub 2011 Jun 8.
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The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis.
Appl Microbiol Biotechnol. 2010 Feb;85(6):1797-807. doi: 10.1007/s00253-009-2193-3. Epub 2009 Aug 26.
6
Isolation and characterization of pcsB, the gene for a polyene carboxamide synthase that tailors pimaricin into AB-400.
Appl Microbiol Biotechnol. 2010 Feb;85(6):1809-19. doi: 10.1007/s00253-009-2195-1. Epub 2009 Aug 26.
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Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase.
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Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.
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