源自α,β-不饱和脂肪酸的盐孢菌素的生物合成：对扩展聚酮合酶多样性的意义
Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.
作者信息
Liu Yuan, Hazzard Christopher, Eustáquio Alessandra S, Reynolds Kevin A, Moore Bradley S
机构信息
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.
出版信息
J Am Chem Soc. 2009 Aug 5;131(30):10376-7. doi: 10.1021/ja9042824.
Abstract
A new series of coenzyme A-tethered polyketide synthase extender units were discovered in relation to the biosynthesis of the salinosporamide family of anticancer agents from the marine bacterium Salinispora tropica. In vivo and in vitro experiments revealed that the crotonyl-CoA reductase/carboxylase SalG has broad substrate tolerance toward 2-alkenyl-CoAs that give rise to the salinosporamide C-2 substitution pattern.
摘要
在与来自热带盐孢菌的抗癌剂盐孢酰胺家族生物合成相关的研究中，发现了一系列新的辅酶A连接的聚酮合酶延伸单元。体内和体外实验表明，巴豆酰辅酶A还原酶/羧化酶SalG对导致盐孢酰胺C-2取代模式的2-烯基辅酶A具有广泛的底物耐受性。
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