多囊卵巢综合征超重成年女性在生活方式改变计划期间的生活质量和体重指数

Quality of Life and Body Mass Index in Overweight Adult Women with Polycystic Ovary Syndrome During a Lifestyle Modification Program.

作者信息

De Frène Veerle, Verhofstadt Lesley, Lammertyn Jan, Stuyver Isabelle, Buysse Ann, De Sutter Petra

出版信息

J Obstet Gynecol Neonatal Nurs. 2015 Sep-Oct;44(5):587-99. doi: 10.1111/1552-6909.12739. Epub 2015 Aug 18.

DOI:10.1111/1552-6909.12739

PMID:26284937

Abstract

OBJECTIVE

To evaluate changes in body mass index (BMI) and health-related quality of life (HRQoL), including an acne parameter, of overweight adult women with polycystic ovary syndrome (PCOS) during a lifestyle modification program.

DESIGN

Prospective longitudinal within-patient study.

SETTING

Department of Reproductive Medicine of the Ghent University Hospital (Belgium).

PARTICIPANTS

Thirty-three overweight (BMI ≥ 25 kg/m²) women with PCOS between age 18 and 43 years.

METHODS

Participants followed a 24-week lifestyle modification program consisting of a diet, exercise, and psychological subprogram. BMI was assessed at Weeks 0, 8, 16, and 24 of the program. The HRQoL was measured at Week 0, 12, and 24 of the program using the PolyCystic Ovary Syndrome Questionnaire (PCOSQ) and a Visual Analogue Scale (VAS) to evaluate the influence of acne on HRQoL.

RESULTS

During a 24-week period no significant decrease in BMI occurred (mean difference = 1.71, 95% confidence interval [CI] [-1.38, 4.81]. During that period, there was a significant positive evolution of the total PCOSQ score, F(2, 37.5) = 23.7, the emotions, F(2, 37.9) = 4.2, weight, F(2, 42.1) = 24.8, body hair, F(2, 35.6) = 3.3, and infertility problems domain scores, F(2, 43.1) = 15.64, of the PCOSQ, as well as of the acne VAS score, F(2, 29.3) = 4.2. These effects primarily occurred during the first 12 weeks.

CONCLUSION

In spite of no significant changes in BMI, the HRQoL of overweight adult women with PCOS significantly improved during a 24-week lifestyle modification program.

摘要

目的

评估超重的多囊卵巢综合征（PCOS）成年女性在生活方式改善计划期间体重指数（BMI）及健康相关生活质量（HRQoL，包括痤疮参数）的变化。

设计

前瞻性纵向患者内研究。

地点

根特大学医院（比利时）生殖医学科。

参与者

33名年龄在18至43岁之间、超重（BMI≥25kg/m²）的PCOS女性。

方法

参与者遵循一项为期24周的生活方式改善计划，该计划包括饮食、运动和心理子计划。在计划的第0、8、16和24周评估BMI。在计划的第0、12和24周使用多囊卵巢综合征问卷（PCOSQ）和视觉模拟量表（VAS）测量HRQoL，以评估痤疮对HRQoL的影响。

结果

在24周期间，BMI没有显著下降（平均差异=1.71，95%置信区间[CI][-1.38，4.81]）。在此期间，PCOSQ的总得分、情绪得分、体重得分、体毛得分和不孕问题领域得分以及痤疮VAS得分均有显著的正向变化，PCOSQ的总得分F(2, 37.5)=23.7，情绪得分F(2, 37.9)=4.2，体重得分F(2, 42.1)=24.8，体毛得分F(2, 35.6)=3.3，不孕问题领域得分F(2, 43.1)=15.64，痤疮VAS得分F(2, 29.3)=4.2。这些影响主要发生在前12周。