一项关于多囊卵巢综合征女性健康相关生活质量的自填式问卷得到了验证。

Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated.

作者信息

Guyatt Gordon, Weaver Bruce, Cronin Lisa, Dooley Julie Ann, Azziz Ricardo

机构信息

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.

出版信息

J Clin Epidemiol. 2004 Dec;57(12):1279-87. doi: 10.1016/j.jclinepi.2003.10.018.

DOI:10.1016/j.jclinepi.2003.10.018

PMID:15617954

Abstract

OBJECTIVE

We examined the measurement properties of a questionnaire (PCOSQ) measuring health-related quality of life (HRQOL) in women with the polycystic ovary syndrome (PCOS).

STUDY DESIGN

This multicenter prospective randomized placebo-controlled blinded study enrolled 393 patients with PCOS at tertiary care sites. Participants were randomized to placebo or troglitazone (150 mg/d, 300 mg/d, or 600 mg/d). At baseline (n=393) and after 44 weeks of treatment (n=284) the proportion of normal menstrual cycles, the free testosterone (T) level, four objective measures of facial hair growth (hair density and hair growth rate by photography, and hair diameter and hair growth rate using plucked hairs), and a subjective assessment of the degree of hirsutism, the modified Ferriman-Gallwey (F-G) score, were determined. At both visits, patients also completed the PCOSQ. Since the trial was conducted, troglitazone has been removed from the market because of toxic effects. The PCOSQ includes 26 questions (items) that address five areas of concern (domains), including emotions, body hair, body weight, fertility, and menstruation rated on a seven-point scales in which lower scores denote higher degrees of patient concern and a lower HRQOL.

RESULTS

Cronbach's alpha was >0.7 for four of five domains. Factor analysis provided moderate to strong support for the five-domain structure of the PCOSQ. Cross-sectional correlations were weak with all measures but the F-G score and hair growth (r=-.46, P < .01). The change in the F-G score showed a statistically significant (P < .01) correlation with changes in PCOSQ hair growth (r=-.22), weight (r=-.17), infertility (r=-.20), and menstruation (r=-.20). Changes in the proportion of normal menstrual cycles correlated with change in the infertility domain (r=.14, P < .03) and with the change in the menstruation domain (r=.31, P < .001). The PCOSQ proved as responsive as the F-G, and more responsive than the objective measures of hair growth, to effects of troglitazone.

CONCLUSIONS

Our data provides some support for the discriminative and longitudinal validity, and appreciable support for the responsiveness, of the PCOSQ.

摘要

目的

我们检验了一份用于测量多囊卵巢综合征（PCOS）女性健康相关生活质量（HRQOL）的问卷（PCOSQ）的测量属性。

研究设计

这项多中心前瞻性随机安慰剂对照双盲研究纳入了393例在三级医疗机构就诊的PCOS患者。参与者被随机分为安慰剂组或曲格列酮组（150mg/d、300mg/d或600mg/d）。在基线期（n = 393）和治疗44周后（n = 284），测定正常月经周期的比例、游离睾酮（T）水平、四项面部毛发增长的客观测量指标（通过摄影测量毛发密度和毛发生长速率，以及使用拔下的毛发测量毛发直径和毛发生长速率），以及多毛症程度的主观评估指标——改良的费里曼-盖尔韦（F-G）评分。在两次就诊时，患者均完成PCOSQ问卷。自该试验开展以来，曲格列酮因毒性作用已退市。PCOSQ包括26个问题（条目），涉及五个关注领域（维度），包括情绪、体毛、体重、生育能力和月经，采用七点量表评分，分数越低表明患者关注程度越高，HRQOL越低。

结果

五个维度中的四个维度的克朗巴哈系数大于0.7。因子分析为PCOSQ的五维度结构提供了中度到有力的支持。除F-G评分和毛发生长外，PCOSQ与所有测量指标的横断面相关性均较弱（r = -0.46，P < 0.01）。F-G评分的变化与PCOSQ中毛发生长（r = -0.22）、体重（r = -0.17）、不孕（r = -0.20）和月经（r = -0.20）的变化呈统计学显著相关（P < 0.01）。正常月经周期比例的变化与不孕维度的变化（r = 0.14，P < 0.03）以及月经维度的变化（r = 0.31，P < 0.001）相关。PCOSQ对曲格列酮治疗效果的反应与F-G评分一样敏感，且比毛发增长的客观测量指标更敏感。