Chaimongkol B, Nanthachit N, Navarawong V, Siriloiratana P
J Med Assoc Thai. 1989 Dec;72(12):666-72.
Forty cases of drug-induced agranulocytosis from the Department of Medicine, Faculty of Medicine, Chiang Mai University during the 12 year period 1975-1987 were analysed. In 32 cases, the related etiologic drugs were identified. These were thiacetazone and isoniazid in 10 cases (25%), propylthiouracil in 6 cases (15%) sulfa drugs in 5 cases (12.5%) combination of analgesic and antibiotics in 3 cases (7.5%), anti-psychotic in 2 cases (5%), antibiotics in 5 cases including, ampicillin (2 cases) and others (3 cases), and ether in 1 case (2.5%). The other 8 cases (20%) received unknown drugs from private clinics. Twenty-four cases had complete recovery in 13-14 days after withdrawal of the incriminating drugs, and sixteen cases (40%) died with septicemia.
对清迈大学医学院内科在1975年至1987年这12年间的40例药物性粒细胞缺乏症病例进行了分析。在32例病例中，确定了相关的致病药物。其中，氨硫脲和异烟肼10例（25%），丙硫氧嘧啶6例（15%），磺胺类药物5例（12.5%），镇痛剂与抗生素联合用药3例（7.5%），抗精神病药物2例（5%），抗生素5例，包括氨苄西林2例和其他3例，乙醚1例（2.5%）。另外8例（20%）从私人诊所接受了不明药物。24例在停用致病药物后13至14天完全康复，16例（40%）死于败血症。
