• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Instant therapy of acquired agranulocytosis and sepsis by recombinant granulocyte-macrophage colony-stimulating factor in a polytrauma patient.

作者信息

Gross-Weege W, Weiss M, Wernet P, Varney M, Becker H

机构信息

Chirurgische Klinik, Abteilung für Allgemeine und Unfallchirurgie, Heinrich-Heine Universität Düsseldorf.

出版信息

Clin Investig. 1993 Oct;71(10):791-4. doi: 10.1007/BF00190320.

DOI:10.1007/BF00190320
PMID:8305835
Abstract

Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was given to an intensive-care patient with polytrauma in a life-threatening situation with acquired agranulocytosis and sepsis. Mature granulocytes reappeared in the blood 2 days after initiation of rhGM-CSF therapy; granulocyte precursors peaked at 43% after 5 days. Bone marrow examination performed 7 days after the beginning of rhGM-CSF therapy revealed complete regeneration of granulopoiesis. The functional analysis of these blood leukocytes in vitro showed regular production of reactive oxygen radicals. Clinically, the patient recovered without any serious side effects due to the rhGM-CSF therapy. These results suggest that rhGM-CSF accelerates granulocyte recovery from acquired agranulocytosis with the presence of their functional activity.

摘要

相似文献

1
Instant therapy of acquired agranulocytosis and sepsis by recombinant granulocyte-macrophage colony-stimulating factor in a polytrauma patient.
Clin Investig. 1993 Oct;71(10):791-4. doi: 10.1007/BF00190320.
2
Rapid neutrophil recovery from acquired agranulocytosis by recombinant human granulocyte-macrophage colony-stimulating factor in an intensive care patient.
Crit Care Med. 1992 Oct;20(10):1490-1. doi: 10.1097/00003246-199210000-00021.
3
Recovery of carbimazole-induced agranulocytosis following recombinant granulocyte-macrophage colony stimulating factor (rhGM-CSF) administration.重组粒细胞-巨噬细胞集落刺激因子（rhGM-CSF）给药后卡比马唑诱导的粒细胞缺乏症的恢复情况。
Haematologica. 1993 Sep-Oct;78(5):329-31.
4
The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia.重组人粒细胞巨噬细胞集落刺激因子对慢性重度中性粒细胞减少症患者中性粒细胞减少及相关发病率的影响。
Ann Intern Med. 1989 Dec 1;111(11):887-92. doi: 10.7326/0003-4819-111-11-887.
5
A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia.一项关于粒细胞巨噬细胞集落刺激因子用于脓毒症和中性粒细胞减少症新生儿的随机试验。
Pediatrics. 2001 Jan;107(1):36-41. doi: 10.1542/peds.107.1.36.
6
Congenital neutropenia: a case study.
Am J Pediatr Hematol Oncol. 1990 Summer;12(2):210-4. doi: 10.1097/00043426-199022000-00017.
7
Granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment of clozapine-induced agranulocytosis: a case report.粒细胞-巨噬细胞集落刺激因子（GM-CSF）治疗氯氮平引起的粒细胞缺乏症：一例报告
J Clin Psychiatry. 1992 Jul;53(7):245-7.
8
In vitro and in vivo activity of human recombinant granulocyte-macrophage colony-stimulating factor in dogs.重组人粒细胞巨噬细胞集落刺激因子在犬体内和体外的活性
Exp Hematol. 1990 Oct;18(9):1026-33.
9
Haematologic effects of granulocyte-macrophage colony stimulating factor in a patient with thiamazole-induced agranulocytosis.粒细胞巨噬细胞集落刺激因子对1例甲巯咪唑所致粒细胞缺乏症患者的血液学影响
J Intern Med. 1992 Nov;232(5):443-5. doi: 10.1111/j.1365-2796.1992.tb00612.x.
10
The use of recombinant human granulocyte-macrophage colony stimulating factor in autologous bone marrow transplantation.重组人粒细胞巨噬细胞集落刺激因子在自体骨髓移植中的应用。
Am J Clin Oncol. 1991;14 Suppl 1:S15-8. doi: 10.1097/00000421-199112001-00004.

本文引用的文献

1
Intra- and extracellular events in luminol-dependent chemiluminescence of polymorphonuclear leukocytes.多形核白细胞鲁米诺依赖性化学发光中的细胞内和细胞外事件
Infect Immun. 1984 Jul;45(1):1-5. doi: 10.1128/iai.45.1.1-5.1984.
2
Haematological aspects of drug-induced agranulocytosis.
Scand J Haematol. 1972;9(1):18-27. doi: 10.1111/j.1600-0609.1972.tb00909.x.
3
Influence of various antimicrobial agents on the chemiluminescence of phagocytosing human granulocytes.
Chemotherapy. 1986;32(1):18-24. doi: 10.1159/000238384.
4
Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.药物性再生障碍性贫血和粒细胞缺乏症。发病率及机制。
Drugs. 1986 Jan;31(1):52-63. doi: 10.2165/00003495-198631010-00004.
5
Functional differentiation of normal human neutrophils.正常人中性粒细胞的功能分化
Blood. 1987 Mar;69(3):937-44.
6
Measurement of phagocyte chemiluminescence in a microtitre plate format.微孔板法检测吞噬细胞化学发光
J Immunol Methods. 1988 Sep 13;112(2):163-8. doi: 10.1016/0022-1759(88)90352-3.
7
The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia.重组人粒细胞巨噬细胞集落刺激因子对慢性重度中性粒细胞减少症患者中性粒细胞减少及相关发病率的影响。
Ann Intern Med. 1989 Dec 1;111(11):887-92. doi: 10.7326/0003-4819-111-11-887.
8
Drug-induced agranulocytosis.药物性粒细胞缺乏症
J Med Assoc Thai. 1989 Dec;72(12):666-72.
9
Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis.重组人粒细胞集落刺激因子对先天性粒细胞缺乏症患者中性粒细胞减少的影响。
N Engl J Med. 1989 Jun 15;320(24):1574-80. doi: 10.1056/NEJM198906153202402.
10
Let's agree on terminology: definitions of sepsis.
Crit Care Med. 1991 Jul;19(7):973-6. doi: 10.1097/00003246-199107000-00024.