玻璃体内注射雷珠单抗治疗视网膜分支静脉阻塞后黄斑裂孔形成：一例报告
Macular hole formation following intravitreal injection of ranibizumab for branch retinal vein occlusion: a case report.
作者信息
Muramatsu Daisuke, Mitsuhashi Ryosuke, Iwasaki Takuya, Goto Hiroshi, Miura Masahiro
机构信息
Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Ami-machi, Inashiki-gun, Ibaraki, 300-0395, Japan.
Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
出版信息
BMC Res Notes. 2015 Aug 19;8:358. doi: 10.1186/s13104-015-1324-4.
BACKGROUND
Macular hole formation after anti-vascular endothelial growth factor therapy is a rare complication. We report macular hole formation after intravitreal ranibizumab injection for branch retinal vein occlusion.
CASE PRESENTATION
A 63-year-old Asian male was treated with intravitreal ranibizumab injection for chronic macular edema with branch retinal vein occlusion in his right eye. Before treatment, best-corrected visual acuity in his right eye was 20/200. Nine days after injection, a full thickness macular hole developed with reduction of macular edema. After pars plana vitrectomy combined with cataract surgery, the macular hole was successfully closed, and the best-corrected visual acuity in his right eye improved to 20/40.
CONCLUSION
The possibility of an infrequent complication like macular hole should be considered for intravitreal ranibizumab for macular edema with branch retinal vein occlusion.
背景
抗血管内皮生长因子治疗后黄斑裂孔形成是一种罕见的并发症。我们报告玻璃体内注射雷珠单抗治疗视网膜分支静脉阻塞后出现黄斑裂孔。
病例介绍
一名63岁的亚洲男性因右眼视网膜分支静脉阻塞伴慢性黄斑水肿接受玻璃体内注射雷珠单抗治疗。治疗前，其右眼最佳矫正视力为20/200。注射9天后，出现全层黄斑裂孔，黄斑水肿减轻。在进行玻璃体切割联合白内障手术后，黄斑裂孔成功闭合，其右眼最佳矫正视力提高到20/40。
结论
对于视网膜分支静脉阻塞伴黄斑水肿的患者，采用玻璃体内注射雷珠单抗治疗时，应考虑黄斑裂孔这种罕见并发症的可能性。
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