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2
Treatment of Inflammatory Macular Hole: Case Series and Review of Literature.炎症性黄斑裂孔的治疗：病例系列及文献复习。
Ocul Immunol Inflamm. 2022 May 19;30(4):966-972. doi: 10.1080/09273948.2020.1867871. Epub 2021 Apr 7.
3
Comparison of intravitreal anti-vascular endothelial growth factor agents and treatment results in Irvine-Gass syndrome.玻璃体内抗血管内皮生长因子药物的比较及在Irvine-Gass综合征中的治疗结果
Int J Ophthalmol. 2020 Oct 18;13(10):1586-1591. doi: 10.18240/ijo.2020.10.12. eCollection 2020.
4
Two cases of diabetic macular edema complicated by an atypical macular hole.两例糖尿病性黄斑水肿合并非典型黄斑裂孔。
BMC Ophthalmol. 2020 Apr 29;20(1):171. doi: 10.1186/s12886-020-01444-7.
5
MACULAR HOLE CLOSURE WITH TOPICAL STEROIDS.局部用皮质类固醇治疗黄斑裂孔闭合。
Retin Cases Brief Rep. 2022 May 1;16(3):351-354. doi: 10.1097/ICB.0000000000000979. Epub 2020 Mar 2.
6
Macular Hole Formation after Intravitreal Injection of Bevacizumab for Diabetic Macular Edema.玻璃体内注射贝伐单抗治疗糖尿病性黄斑水肿后黄斑裂孔的形成
Korean J Ophthalmol. 2019 Apr;33(2):198-199. doi: 10.3341/kjo.2018.0079.
7
Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes.特发性全层黄斑裂孔的局部水性抑制与封闭
Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):e38-e43. doi: 10.3928/23258160-20190129-17.
8
ATYPICAL MACULAR HOLES.非典型性黄斑裂孔。
Retina. 2019 Jul;39(7):1236-1264. doi: 10.1097/IAE.0000000000002448.
9
Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema: recent clinically relevant findings from DRCR.net Protocol T.阿柏西普、贝伐单抗或雷珠单抗治疗糖尿病性黄斑水肿：DRCR.net方案T的近期临床相关研究结果
Curr Opin Ophthalmol. 2017 Nov;28(6):636-643. doi: 10.1097/ICU.0000000000000424.
10
Case report of a secondary macular hole closure after intravitreal bevacizumab therapy in a patient with retinal pigment epithelial detachment.视网膜色素上皮脱离患者玻璃体内注射贝伐单抗治疗后继发性黄斑裂孔闭合的病例报告。
Indian J Ophthalmol. 2017 Jul;65(7):632-633. doi: 10.4103/ijo.IJO_818_16.

在一只患有糖尿病性黄斑水肿的眼睛中，单次玻璃体内注射阿柏西普后全层黄斑裂孔闭合

Full-Thickness Macular Hole Closure Following a Single Intravitreal Injection of Aflibercept in an Eye With Diabetic Macular Edema.

作者信息

Sharpless Michael, Hogden Michael

机构信息

Department of Ophthalmology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.

出版信息

J Vitreoretin Dis. 2022 May 5;6(6):457-460. doi: 10.1177/24741264221083415. eCollection 2022 Nov-Dec.

DOI:10.1177/24741264221083415
PMID:37009537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9954781/
Abstract

PURPOSE

This work aims to discuss the case of a 32-year-old man with diabetic macular edema (DME) who underwent successful treatment of a full-thickness macular hole (FTMH) with a single dose of aflibercept.

METHODS

A case report is presented.

RESULTS

A 32-year-old man with reduced vision and DME in the right eye was found to have a FTMH. The patient was scheduled for pars plana vitrectomy; however, following a single dose of intravitreal aflibercept, the FTMH closed and the patient avoided surgical intervention.

CONCLUSIONS

FTMH formation in DME is a rare complication that typically requires surgical intervention. We present a case of FTMH closure after a single dose of intravitreal aflibercept, which to our knowledge is the first of its kind. This report highlights the importance of considering conservative treatment initially to avoid surgery.

摘要

目的

本研究旨在探讨一名32岁患有糖尿病性黄斑水肿（DME）的男性患者，其单剂量阿柏西普成功治疗了全层黄斑裂孔（FTMH）的病例。

方法

呈现一例病例报告。

结果

一名32岁右眼视力下降且患有DME的男性被发现有FTMH。该患者原计划行玻璃体切除术；然而，在单剂量玻璃体内注射阿柏西普后，FTMH闭合，患者避免了手术干预。

结论

DME中FTMH的形成是一种罕见的并发症，通常需要手术干预。我们报告了一例单剂量玻璃体内注射阿柏西普后FTMH闭合的病例，据我们所知，这是首例此类病例。本报告强调了最初考虑保守治疗以避免手术的重要性。