Märker David A, Radeck Viola, Lehmann Fabian, Barth Teresa, Helbig Horst, Eter Nicole, Alten Florian, Clemens Christoph R
Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, 93053, Regensburg, Deutschland, Franz-Josef-Strauss Allee 11.
Klinik für Augenheilkunde, Carl-Thiem Klinikum-Cottbus, Cottbus, Deutschland.
Ophthalmologie. 2024 Feb;121(2):129-134. doi: 10.1007/s00347-023-01976-5. Epub 2024 Jan 12.
Intravitreal operative drug injections represent one of the most frequently performed medical interventions. The risk profile is low. In addition to intraocular pressure elevation, the most frequent complications include exogenous endophthalmitis, vitreous hemorrhage and rhegmatogenous retinal detachment. Furthermore, isolated cases of lens injuries, macular holes associated with vitreoretinal traction and peripheral retinal defects have been described. In the present case series sharp iatrogenic macular and retinal defects are described.
Retrospective multicenter case collection of patients with iatrogenic retinal defects after intravitreal injections from 2016 to 2023.
Iatrogenic retinal trauma after intravitreal injections for treatment of neovascular age-related macular degeneration was identified in 9 cases (72 years ± 8.1, 3 eyes pseudophakic). While sharp injuries within the macula occurred in six cases, extramacular lesions were detected in the other cases.
Iatrogenic retinal and macular injuries are rare complications of intravitreal injections and when correctly carried out are preventable, especially with respect to use of cannulas and the choice of the distance from the limbus.
玻璃体内手术药物注射是最常进行的医疗干预措施之一。风险较低。除眼压升高外，最常见的并发症包括外源性眼内炎、玻璃体积血和孔源性视网膜脱离。此外，还描述了孤立的晶状体损伤、与玻璃体视网膜牵引相关的黄斑裂孔和周边视网膜缺损病例。在本病例系列中，描述了医源性黄斑和视网膜锐性缺损。
回顾性多中心收集2016年至2023年玻璃体内注射后发生医源性视网膜缺损的患者病例。
在9例患者（72岁±8.1岁，3只眼为人工晶状体眼）中发现了因玻璃体内注射治疗新生血管性年龄相关性黄斑变性导致的医源性视网膜损伤。其中6例发生黄斑内锐性损伤，其他病例检测到黄斑外病变。
医源性视网膜和黄斑损伤是玻璃体内注射的罕见并发症，若操作正确则可预防，尤其是在使用套管以及选择距角膜缘的距离方面。
