Datubo-Brown D D, Kejeh B M
J R Coll Surg Edinb. 1989 Dec;34(6):328-31.
Thirty-nine children with congenital cleft deformities seen at the University of Port Harcourt Teaching Hospital over a four-year period (1984-87) were studied. The majority (69%) of the children came from PHALGA, OTELGA and ALGA, the areas of the state with a high concentration of oil wells, gas flares and a petroleum refinery. There is yet no proof that there is a cause and effect relationship between the deformities and the industrial pollution but attention has been drawn to the association, which may be real or apparent. Further prospective studies are indicated. Apart from the possible role of environmental pollution, other epidemiological factors discussed include parental age, socioeconomic class of the families and the significance of the absence of positive family history of cleft deformities in all the cases studied.
对哈科特港大学教学医院在四年期间（1984 - 1987年）收治的39例先天性腭裂畸形患儿进行了研究。大多数（69%）患儿来自PHALGA、OTELGA和ALGA，这些地区是该州油井、天然气火炬和炼油厂高度集中的区域。目前尚无证据表明畸形与工业污染之间存在因果关系，但已有人关注到这种关联，其可能是真实的，也可能是表面的。需要进一步开展前瞻性研究。除了环境污染可能起到的作用外，讨论的其他流行病学因素还包括父母年龄、家庭的社会经济阶层以及在所有研究病例中均无腭裂畸形家族史阳性的意义。
