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食管内白色肿物——一项具有挑战性的诊断。

Intra-esophageal whitish mass - a challenging diagnosis.

作者信息

Ciobanu Lidia, Pascu Oliviu, Tantau Marcel, Pinzariu Oana, Furnea Bogdan, Botan Emil, Taulescu Marian

机构信息

Regional Institute of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Croitorilor Street 19-21, Cluj-Napoca, 400162, Romania.

Emergency Clinic Country Hospital, Cluj-Napoca, 400006, Romania.

出版信息

BMC Gastroenterol. 2015 Aug 19;15:106. doi: 10.1186/s12876-015-0335-x.

Abstract

BACKGROUND

Whitish intraluminal esophageal masses might represent the endoscopic feature of a bezoar or a pedunculated tumor, most likely a fibrovascular polyp, without exclusion of other mesenchymal tumors (leiomyoma, lipoma, gastrointestinal stromal tumor, leiomyosarcoma, granular cell tumor). If a process of dystrophic calcification is also encountered the differential diagnosis can be a challenge even after histological analysis, as it is highlighted by our case.

CASE PRESENTATION

A 65-year-old female whom took lactate calcium tablets for 5 years presented with progressive dysphagia. A whitish esophageal mass with an appearance of a pharmacobezoar was detected at esophagoscopy. A pedunculated tumor was considered in the differential diagnosis, but the imagistic studies ruled out a pedicle. This intraluminal esophageal mass highly suggestive for a pharmacobezoar was endoscopically removed. The challenge of correct diagnosis was raised by histological examination performed after immersion into trichloracetic acid for decalcification. The identification of hyaline fibrous tissue, with numerous crystalline basophils deposits of minerals, rare fibrocytes and very few vessels brought in discussion a mesenchymal originating mass, most likely a fibrovascular polyp, even the pedicle was not detected.

CONCLUSION

Based on our challenging and difficult to diagnose case we proposed an uncommon evolution: auto-amputation and calcification of an esophageal mesenchymal originating tumor (most likely a fibrovascular polyp).

摘要

背景

食管腔内白色肿物可能表现为胃石或带蒂肿瘤的内镜特征,最可能是纤维血管性息肉,也不排除其他间叶组织肿瘤(平滑肌瘤、脂肪瘤、胃肠道间质瘤、平滑肌肉瘤、颗粒细胞瘤)。如果还存在营养不良性钙化过程,即使经过组织学分析,鉴别诊断也可能具有挑战性,正如我们的病例所强调的那样。

病例介绍

一名65岁女性,服用乳酸钙片5年,出现进行性吞咽困难。食管镜检查发现一个外观似药石性胃石的白色食管肿物。鉴别诊断考虑为带蒂肿瘤,但影像学检查排除了蒂的存在。这个高度提示为药石性胃石的食管腔内肿物经内镜切除。在浸入三氯乙酸进行脱钙后进行的组织学检查引发了正确诊断的难题。透明纤维组织的鉴定,伴有大量矿物质结晶性嗜碱性沉积物、罕见的纤维细胞和极少的血管,提示为间叶组织起源的肿物,最可能是纤维血管性息肉,尽管未检测到蒂。

结论

基于我们这个具有挑战性且难以诊断的病例,我们提出了一种不常见的演变过程:食管间叶组织起源的肿瘤(最可能是纤维血管性息肉)发生自截和钙化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5064/4544799/57ff8e9e007d/12876_2015_335_Fig1_HTML.jpg

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