Giermaziak H
Ze Szpitala WUSW w Lodzi.
Med Pr. 1989;40(4):228-37.
Pathomorphological changes of the cardiac muscle of experimental rabbits and rats intoxicated with Intration were traced. Diffuse ischaemic lesions such as the presence of large quantities of mitochondria, contraction nodes and droplet necrosis were observed. These lesions result: from the toxic effect of pesticides on myocytes and inhibition of cholinesterases as well as from nonphysiologically great activity of lysosome enzymex which are also responsible for necrotic lesions in the cardiac muscle. Excessively high PAM doses administered to animals intoxicated with pesticide result in lesions in the cardiac muscle of rabbits and rats which are greater than after administering an insectide alone. Toxobidin, a multi-function compound, doses not possess such negative properties as PAM.
对用因曲磷中毒的实验兔和大鼠的心肌病理形态学变化进行了追踪研究。观察到弥漫性缺血性病变，如大量线粒体、收缩节和滴状坏死的存在。这些病变是由农药对心肌细胞的毒性作用、胆碱酯酶的抑制以及溶酶体酶的非生理性高活性导致的，溶酶体酶也与心肌的坏死性病变有关。给农药中毒的动物过量施用解磷定导致兔和大鼠心肌出现的病变比单独施用杀虫剂后更严重。多功能化合物毒扁豆碱不具有解磷定这样的负面特性。
