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兔急性中毒注射Intration后及用某些解毒剂治疗后的心肌和心内膜病变

Myocardial and endocardial lesions in rabbit after acute poisoning with Intration and after treatment with some detoxifying agents.

作者信息

Biernat S, Giermaziak H

出版信息

Pol Med Sci Hist Bull (1973). 1975 Mar-Apr;15(2):249-53.

PMID:1241438
Abstract

The hearts of rabbits killed 24 hours after intoxication with Intration in the dose of LD50 and rabbits treated at the same time with PAM or atropine were studied pathomorphologically. Twenty-four hours after administration of Intration toxic lesions of the myocardium and endocardium were observed, which were more pronounced in rabbits treated simultaneously with the detoxifying agents as compared with those which received only Intration. The intensity of the changes was due to overdosage of the detoxifying agents, especially PAM which was particularly harmful.

摘要

对以半数致死量(LD50)剂量的英曲安奈德(Intration)中毒24小时后处死的兔子以及同时用解磷定(PAM)或阿托品治疗的兔子的心脏进行了病理形态学研究。给予英曲安奈德24小时后,观察到心肌和心内膜的中毒性病变,与仅接受英曲安奈德的兔子相比,同时用解毒剂治疗的兔子的病变更为明显。变化的强度归因于解毒剂过量,尤其是解磷定,其危害特别大。

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Pol Med Sci Hist Bull (1973). 1975 Mar-Apr;15(2):249-53.
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