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三代人中的单纯强迫障碍

Pure Obsessive Compulsive Disorder in Three Generations.

作者信息

Rahimi Alireza, Haghighi Mohammad, Shamsaei Farshid

机构信息

Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, IR Iran.

出版信息

Iran J Psychiatry Behav Sci. 2015 Jun;9(2):e1116. doi: 10.17795/ijpbs1116. Epub 2015 Jun 1.

DOI:10.17795/ijpbs1116
PMID:26288641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4539584/
Abstract

INTRODUCTION

Obsessive-compulsive disorder (OCD) is a psychiatric disorder, which has been shown to affect 2 - 3.5% of people, during their lifetimes. Identification of familial more homogenous characteristics of OCD may help to define relevant subtypes and increase the power of genetic and neurobiological studies of OCD.

CASE PRESENTATION

This case report describes an adult woman suffering from symptoms of energy loss, insomnia, lack of appetite, and depressed mood. The patient history was positive for counting coercion. The patient's genogram revealed counting coercion in three generations of her family.

CONCLUSIONS

This case highlights the issue whether counting can be a distinctive feature among inflicted and not inflicted individuals, such as hoarding. Also, it is still unclear what is it really transferred; the vulnerability to disease, which is transferred among three generations, or the symptoms of counting itself, by genes. Further studies are required to answer the debates on this issue.

摘要

引言

强迫症(OCD)是一种精神疾病,已证实在人们的一生中会影响2%至3.5%的人群。确定强迫症在家族中更具同质性的特征,可能有助于定义相关亚型,并提高强迫症基因和神经生物学研究的效力。

病例报告

本病例报告描述了一名成年女性,她出现了精力丧失、失眠、食欲不振和情绪低落等症状。患者病史显示有计数强迫症状呈阳性。患者的系谱图显示其家族三代人都有计数强迫症状。

结论

本病例突出了一个问题,即计数是否会像囤积一样,成为患病和未患病个体之间的一个显著特征。此外,目前仍不清楚真正传递的是什么:是三代人之间传递的疾病易感性,还是通过基因传递的计数症状本身。需要进一步的研究来回答关于这个问题的争论。

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本文引用的文献

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Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts.强迫症及其相关障碍:对强迫谱系概念的重新评估
Dialogues Clin Neurosci. 2010;12(2):131-48. doi: 10.31887/DCNS.2010.12.2/dmurphy.
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The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.《全国共病调查再研究中的强迫症流行病学》。
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Obsessive beliefs in first-degree relatives of patients with OCD: a test of the cognitive vulnerability model.
强迫症患者一级亲属中的强迫观念:认知易感性模型的一项检验
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Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.全国共病调查复制研究中 DSM-IV 障碍的终生患病率和发病年龄分布
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A multidimensional model of obsessive-compulsive disorder.强迫症的多维模型。
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A family study of obsessive-compulsive disorder with pediatric probands.一项以儿童先证者为对象的强迫症家族研究。
Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):13-9. doi: 10.1002/ajmg.b.30138.
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Obsessive-compulsive disorder phenotypes: implications for genetic studies.强迫症表型:对遗传学研究的启示
Mol Psychiatry. 2005 Mar;10(3):258-75. doi: 10.1038/sj.mp.4001617.
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Obsessive-compulsive severity spectrum in the community: prevalence, comorbidity, and course.社区中的强迫障碍严重程度谱:患病率、共病情况及病程
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