Alsheikh Ahmed M, Alsheikh Maram M
Medicine, College of Medicine, Almaarefa University, Riyadh, SAU.
Epidemiology and Public Health, Faculty of Medicine, Suez Canal University, Ismalia, EGY.
Cureus. 2021 May 1;13(5):e14791. doi: 10.7759/cureus.14791.
Obsessive-compulsive disorder (OCD) is a common mental illness that can significantly impair the patients' quality of life. Recent studies have shown that patients with this condition usually suffer from inflammatory or rheumatological comorbidities. However, the association between OCD's etiology and inflammation is still controversial. This review aims to explore the correlation between OCD and rheumatological as well as inflammatory disorders based on studies conducted in the last decade. A total of eight articles that were deemed eligible were included in the final assessment, involving 31,204 OCD patients from various countries. The most significant inflammatory biomarkers examined were tumor necrosis factor-alpha (TNF-α), interleukins, neutrophil-to-lymphocyte ratio (NLR), and cytokines. We concluded that the pathophysiology and etiology of OCD are strongly correlated with inflammatory biomarkers. This finding warrants future studies on the efficacy of anti-inflammatory agents to treat OCD, particularly in the early stages of the disease.
强迫症（OCD）是一种常见的精神疾病，会严重损害患者的生活质量。最近的研究表明，患有这种疾病的患者通常还患有炎症性或风湿性合并症。然而，强迫症的病因与炎症之间的关联仍存在争议。本综述旨在基于过去十年进行的研究，探讨强迫症与风湿性疾病以及炎症性疾病之间的相关性。最终评估共纳入了八篇被认为合格的文章，涉及来自不同国家的31204名强迫症患者。检测的最重要的炎症生物标志物包括肿瘤坏死因子-α（TNF-α）、白细胞介素、中性粒细胞与淋巴细胞比值（NLR）和细胞因子。我们得出结论，强迫症的病理生理学和病因与炎症生物标志物密切相关。这一发现值得未来开展关于抗炎药物治疗强迫症疗效的研究，尤其是在疾病的早期阶段。
