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慢性阻塞性肺疾病(COLD)患者的夜间低氧血症和心律失常

[Nocturnal hypoxemia and arrhythmia in patients with chronic obstructive lung diseases (COLD)].

作者信息

Skwarski K

出版信息

Pol Arch Med Wewn. 1989 May;81(5):283-94.

PMID:2628958
Abstract

A decrease in the arterial blood saturation by oxygen in patients with POChP is a frequent phenomenon. It is more serious in patients type blue boaters and less frequent among patients type pink puffers. The aim of the paper was to compare the arterial blood saturation by oxygen in the groups examined during two nights: during the first night the patients breathed atmospheric air whereas during the second night they were given oxygen. The author also studied the influence of oxygenation of an organism on the frequency of cardiac rhythm disorders (ZRS). The author examined a group of 20 patients with the predominance of chronic bronchitis--blue boaters (average VC was 1.95 l, FEV1--0.81 l, PaO2 while breathing atmospheric air 52 mm Hg and 68 mm Hg after giving oxygen, PaCO2 47 and 51 mm Hg respectively) and 20 patients with the predominance of emphysema--pink puffers (average VC--2.30 l, FEV1--0.86 l, PaO2 while breathing atmospheric air 60 mm Hg and 70 mm Hg after giving oxygen, PaCO2 39 and 40 mm respectively). It was found that the patients with heavy hypoxaemia and hypercapnia had worse arterial blood saturation by oxygen during the two nights of investigation in comparison with the other group. The author also found more frequent cardiac rhythm disorders in this group of patients. Giving oxygen improved blood oxygenation in the two groups and lowered the frequency of cardiac rhythm disorders. The results obtained indicate to the need of oxygen therapy in patients with advanced POChP, especially during the night so as to avoid nocturnal hypoxaemia of an organism.

摘要

原发性慢性阻塞性肺疾病(POChP)患者动脉血氧饱和度降低是一种常见现象。在蓝肿型患者中更为严重,在粉喘型患者中则较少见。本文的目的是比较两组患者在两个晚上检查期间的动脉血氧饱和度:第一个晚上患者呼吸大气,第二个晚上给予吸氧。作者还研究了机体氧合对心律失常(ZRS)发生率的影响。作者检查了一组以慢性支气管炎为主的20例患者——蓝肿型(平均肺活量为1.95升,第一秒用力呼气量——0.81升,呼吸大气时动脉血氧分压为52毫米汞柱,吸氧后为68毫米汞柱,动脉血二氧化碳分压分别为47和51毫米汞柱)和20例以肺气肿为主的患者——粉喘型(平均肺活量——2.30升,第一秒用力呼气量——0.86升,呼吸大气时动脉血氧分压为60毫米汞柱,吸氧后为70毫米汞柱,动脉血二氧化碳分压分别为39和40毫米汞柱)。结果发现,与另一组相比,重度低氧血症和高碳酸血症患者在两个晚上的研究期间动脉血氧饱和度更差。作者还发现该组患者心律失常更频繁。吸氧改善了两组患者的血液氧合,降低了心律失常的发生率。所得结果表明,晚期POChP患者需要进行氧疗,尤其是在夜间,以避免机体夜间低氧血症。

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