Hariri Susan, Markowitz Lauri E, Bennett Nancy M, Niccolai Linda M, Schafer Sean, Bloch Karen, Park Ina U, Scahill Mary W, Julian Pamela, Abdullah Nasreen, Levine Diane, Whitney Erin, Unger Elizabeth R, Steinau Martin, Bauer Heidi M, Meek James, Hadler James, Sosa Lynn, Powell Suzanne E, Johnson Michelle L
Emerg Infect Dis. 2015 Sep;21(9):1557-61. doi: 10.3201/eid2109.141841.
In 2007, five Emerging Infections Program (EIP) sites were funded to determine the feasibility of establishing a population-based surveillance system for monitoring the effect of human papillomavirus (HPV) vaccine on pre-invasive cervical lesions. The project involved active population-based surveillance of cervical intraepithelial neoplasia grades 2 and 3 and adenocarcinoma in situ as well as associated HPV types in women >18 years of age residing in defined catchment areas; collecting relevant clinical information and detailed HPV vaccination histories for women 18-39 years of age; and estimating the annual rate of cervical cancer screening among the catchment area population. The first few years of the project provided key information, including data on HPV type distribution, before expected effect of vaccine introduction. The project's success exemplifies the flexibility of EIP's network to expand core activities to include emerging surveillance needs beyond acute infectious diseases. Project results contribute key information regarding the impact of HPV vaccination in the United States.
2007年，五个新兴传染病项目（EIP）站点获得资助，以确定建立一个基于人群的监测系统的可行性，该系统用于监测人乳头瘤病毒（HPV）疫苗对宫颈上皮内瘤变的影响。该项目涉及对居住在特定集水区、年龄大于18岁的女性进行基于人群的主动监测，监测宫颈上皮内瘤变2级和3级以及原位腺癌，以及相关的HPV类型；收集18 - 39岁女性的相关临床信息和详细的HPV疫苗接种史；并估计集水区人群中宫颈癌筛查的年发生率。该项目的头几年提供了关键信息，包括在疫苗引入预期效果之前的HPV类型分布数据。该项目的成功体现了EIP网络的灵活性，即能够扩展核心活动，以纳入急性传染病之外的新出现的监测需求。项目结果为美国HPV疫苗接种的影响提供了关键信息。
