Section of Pediatric Infectious Diseases, Departments of Pediatrics and Medicine, and Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts.
AIDS. 2018 Apr 24;32(7):851-860. doi: 10.1097/QAD.0000000000001773.
To determine the magnitude and persistence of quadrivalent human papillomavirus (HPV)16 and HPV18 B-cell and T-cell memory after three or four doses of quadrivalent HPV vaccine (QHPV) in HIV-infected children.
Seventy-four HIV-infected children immunized with four doses and 23 with three doses of QHPV had HPV16 and HPV18 IgG B-cell and IFNγ and IL2 T-cell ELISPOT performed at 2, 3.5 and 4-5 years after the last dose.
HPV16 and HPV18 T-cell responses were similar in both treatment groups, with higher responses to HPV16 vs. HPV18. These HPV T-cell responses correlated with HIV disease characteristics at the study visits. Global T-cell function declined over time as measured by nonspecific mitogenic stimulation. B-cell memory was similar across treatment groups and HPV genotypes. There was a decline in HPV-specific B-cell memory over time that reached statistical significance for HPV16 in the four-dose group.
B-cell and T-cell memory did not significantly differ after either three or four doses of QHPV in HIV-infected children. The clinical consequences of decreasing global T-cell function and HPV B-cell memory over time in HIV-infected children requires further investigation.
确定在感染 HIV 的儿童中接种四价人乳头瘤病毒（HPV）疫苗（QHPV）三剂或四剂后，HPV16 和 HPV18 B 细胞和 T 细胞记忆的程度和持久性。
74 名接受四剂 QHPV 免疫的 HIV 感染儿童和 23 名接受三剂 QHPV 免疫的儿童在最后一剂后 2、3.5 和 4-5 年进行了 HPV16 和 HPV18 IgG B 细胞和 IFNγ 和 IL2 T 细胞 ELISPOT。
两组治疗组的 HPV16 和 HPV18 T 细胞反应相似，HPV16 对 HPV18 的反应更高。这些 HPV T 细胞反应与研究期间的 HIV 疾病特征相关。非特异性有丝分裂刺激测量的全球 T 细胞功能随时间下降。B 细胞记忆在各组和 HPV 基因型之间相似。随着时间的推移，HPV 特异性 B 细胞记忆下降，四剂组 HPV16 达到统计学意义。
在感染 HIV 的儿童中，接种三剂或四剂 QHPV 后，B 细胞和 T 细胞记忆没有显著差异。随着时间的推移，HIV 感染儿童的全球 T 细胞功能和 HPV B 细胞记忆下降的临床后果需要进一步研究。
