Baran A, Swiderska M, Flisiak I
a Department of Dermatology and Venereology and.
b Department of Infectious Diseases and Hepatology , Medical University of Bialystok , Bialystok , Poland.
J Dermatolog Treat. 2016;27(2):114-9. doi: 10.3109/09546634.2015.1079300. Epub 2015 Sep 4.
Psoriasis has been considered as chronic systemic disease. Retinol-binding protein-4 (RBP-4) might play a role in psoriasis and its comorbidities. The aim of this study was to investigate the associations between serum RBP-4 levels and disease severity, indicators of inflammation or metabolic syndrome and changes after topical treatment in psoriatic patients.
Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were examined. Blood samples were collected before and after 14 days of therapy. Serum RBP-4 concentrations were examined by enzyme-linked immunosorbent assay for correlation with psoriasis area and severity index (PASI), body mass index (BMI), inflammatory and biochemical markers and with efficacy of topical treatment.
RBP-4 serum levels were increased in psoriatics compared to the controls, but without statistical significance (p = 0.2). No significant correlations between investigated adipokine and several indicators of metabolic disorders, nor BMI or PASI were found. A significant negative correlation with CRP was noted. After topical treatment serum RBP-4 level did not significantly change (p = 0.3), despite clinical improvement.
RBP-4 might have a protective role in terms of chronic inflammation and comorbidities of psoriasis. The adipokine is presumably not useful in determining severity and the effectiveness of antipsoriatic treatment.
银屑病被认为是一种慢性全身性疾病。视黄醇结合蛋白4（RBP - 4）可能在银屑病及其合并症中起作用。本研究的目的是探讨银屑病患者血清RBP - 4水平与疾病严重程度、炎症指标或代谢综合征之间的关联，以及局部治疗后的变化。
对37例斑块型银屑病复发患者和16名健康志愿者进行检查。在治疗14天前后采集血样。通过酶联免疫吸附测定法检测血清RBP - 4浓度，以分析其与银屑病面积和严重程度指数（PASI）、体重指数（BMI）、炎症和生化标志物以及局部治疗疗效的相关性。
与对照组相比，银屑病患者的血清RBP - 4水平升高，但无统计学意义（p = 0.2）。未发现所研究的脂肪因子与代谢紊乱的几个指标、BMI或PASI之间存在显著相关性。但发现与CRP呈显著负相关。尽管临床症状有所改善，但局部治疗后血清RBP - 4水平未显著变化（p = 0.3）。
RBP - 4在银屑病的慢性炎症和合并症方面可能具有保护作用。该脂肪因子可能无助于确定银屑病的严重程度和治疗效果。
