Bagger-Sjöbäck Dan, Strömbäck Karin, Hultcrantz Malou, Papatziamos Georgios, Smeds Henrik, Danckwardt-Lillieström Niklas, Tideholm Bo, Johansson Ann, Hellström Sten, Hakizimana Pierre, Fridberger Anders
Department of Otolaryngology, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Sci Rep. 2015 Aug 21;5:13341. doi: 10.1038/srep13341.
Otosclerosis is a common disorder that leads to conductive hearing loss. Most patients with otosclerosis also have tinnitus, and surgical treatment is known to improve hearing as well as tinnitus. Some patients however experience worsening of tinnitus after the operation, but there are no known factors that allow surgeons to predict who will be at risk. In this prospective observational study on 133 patients undergoing stapedotomy, we show that postoperative air conduction thresholds at very high stimulus frequencies predict improvement of tinnitus, as assessed with proportional odds logistic regression models. Young patients were significantly more likely to experience reduction of tinnitus and patients whose tinnitus became better were also more satisfied with the outcome of the operation. These findings have practical importance for patients and their surgeons. Young patients can be advised that surgery is likely to be beneficial for their tinnitus, but a less positive message should be conveyed to older patients.
耳硬化症是一种导致传导性听力损失的常见疾病。大多数耳硬化症患者也伴有耳鸣,并且已知手术治疗可改善听力以及耳鸣症状。然而,一些患者在术后耳鸣症状会加重,但目前尚无已知因素能让外科医生预测哪些患者会面临这种风险。在这项针对133例行镫骨切除术患者的前瞻性观察研究中,我们发现,通过比例优势逻辑回归模型评估,极高刺激频率下的术后气导阈值可预测耳鸣症状的改善情况。年轻患者耳鸣减轻的可能性显著更高,耳鸣症状改善的患者对手术结果也更满意。这些发现对患者及其外科医生具有实际意义。对于年轻患者,可以告知他们手术可能对其耳鸣有益,但对于老年患者,则应传达不那么乐观的信息。