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[慢性肾衰竭患者反复血液透析治疗中肝损伤时血清酸性α1-糖蛋白、触珠蛋白、补体C 3c成分及免疫球蛋白IgG、IgA和IgM水平]

[Serum levels of acid alpha 1-glycoprotein, haptoglobin, C 3c component of the complement and immunoglobulins IgG, IgA and IgM in liver damage in patients with chronic renal failure treated by repeated hemodialysis].

作者信息

Bartelik S, Starzyk J

出版信息

Wiad Lek. 1989 Apr 30;42(8):520-4.

PMID:2629317
Abstract

Thirty-five patients with chronic renal failure treated with repeated haemodialyses were divided into 3 groups: without evidence of hepatocellular damage (n = 11), with HBs-negative hepatocellular damage (n = 13), with HBS-positive, HBe-positive hepatocellular damage (n = 10). The concentrations of acid alpha 1-glycoprotein, haptoglobin, C3c complement component, IgG, IgA, IgM were determined in the serum before haemodialysis. The serum concentration of acid alpha 1-glycoprotein was statistically significantly higher in the patients in comparison with the healthy subjects. The concentrations of haptoglobin and C3c complement component in the serum were not statistically significantly different form those in healthy controls. The serum levels of IgG, IgA and IgM in patients with hepatocellular damage HBs-positive and HBe-positive were statistically significantly higher in relation to healthy subjects, the serum IgG level in this group was statistically significantly higher than in the group without hepatocellular damage and the group with HBs-negative hepatocellular damage.

摘要

35例接受重复血液透析治疗的慢性肾衰竭患者被分为3组:无肝细胞损伤证据组(n = 11)、HBs阴性肝细胞损伤组(n = 13)、HBs阳性、HBe阳性肝细胞损伤组(n = 10)。在血液透析前测定血清中酸性α1-糖蛋白、触珠蛋白、补体C3c成分、IgG、IgA、IgM的浓度。与健康受试者相比,患者血清中酸性α1-糖蛋白浓度在统计学上显著更高。血清中触珠蛋白和补体C3c成分的浓度与健康对照者相比无统计学显著差异。HBs阳性和HBe阳性肝细胞损伤患者的血清IgG、IgA和IgM水平相对于健康受试者在统计学上显著更高,该组血清IgG水平在统计学上显著高于无肝细胞损伤组和HBs阴性肝细胞损伤组。

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