Laafira Aminath, White Scott W, Griffin Christopher J, Graham Dorothy
King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
School of Women's and Infants' Health, The University of Western Australia, Subiaco, Western Australia, Australia.
Aust N Z J Obstet Gynaecol. 2016 Feb;56(1):36-41. doi: 10.1111/ajo.12394. Epub 2015 Aug 21.
There is debate as to the most appropriate diagnostic criteria to diagnose gestational diabetes mellitus (GDM). The proposed International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria have recently been endorsed by various bodies, but there remains no national consensus.
To assess the perinatal outcomes of women with GDM classified according to the 1998 Australasian Diabetes in Pregnancy Society (ADIPS) criteria compared to those with GDM by the IADPSG criteria.
Results of glucose tolerance tests performed between January 2011 and January 2014 were linked with the perinatal data of those who delivered singleton fetuses after 24 weeks' gestation. Analysed data included birthweight, gestational age at birth, macrosomia, mode of delivery, perinatal mortality, nursery admission, maternal body mass index, and gestational weight gain.
Of 3571 women, 466 (13%) and 559 (16%) met the criteria for the 1998 ADIPS and IADPSG criteria for GDM, respectively. Those with GDM according to the IADPSG criteria only (6%) were more obese (95% CI 2.3-4.8 kg/m(2) ), delivered neonates on average 106 g heavier (95% CI 19-193 g) and had more fetal macrosomia (18% vs 11%, P = 0.002) than those with normal glucose tolerance.
The IADPSG criteria for GDM identified a group of women at previously unrecognised increased risk of adverse perinatal outcomes. Adopting the IADPSG criteria would increase the number of women diagnosed with GDM by 20%; however, the improvements in perinatal morbidity, in addition to potential long-term benefits, may justify the increase in healthcare workload.
关于诊断妊娠期糖尿病(GDM)的最合适诊断标准存在争议。国际糖尿病与妊娠研究组协会(IADPSG)提出的标准最近已得到多个机构的认可,但仍未达成全国共识。
评估根据1998年澳大利亚妊娠糖尿病协会(ADIPS)标准分类的GDM女性与根据IADPSG标准诊断为GDM的女性的围产期结局。
将2011年1月至2014年1月期间进行的葡萄糖耐量试验结果与妊娠24周后分娩单胎胎儿的产妇围产期数据相关联。分析的数据包括出生体重、出生时的孕周、巨大儿、分娩方式、围产期死亡率、新生儿重症监护病房入院情况、产妇体重指数和孕期体重增加。
在3571名女性中,分别有466名(13%)和559名(16%)符合1998年ADIPS和IADPSG的GDM诊断标准。仅根据IADPSG标准诊断为GDM的女性(6%)比糖耐量正常的女性更肥胖(95%可信区间2.3 - 4.8kg/m²),所分娩的新生儿平均重106g(95%可信区间19 - 193g),且巨大儿更多(18%对11%,P = 0.002)。
IADPSG的GDM诊断标准识别出了一组围产期不良结局风险增加但此前未被认识到的女性。采用IADPSG标准将使诊断为GDM的女性数量增加20%;然而,围产期发病率的改善以及潜在的长期益处可能足以证明医疗保健工作量的增加是合理的。