晚期阿尔茨海默病中的非平静与阿明诺夫痛苦综合征
Not Calm and Aminoff Suffering Syndrome in Advanced Alzheimer's Disease.
作者信息
Aminoff Bechor Zvi
机构信息
The Minerva Center for the Interdisciplinary Study of End-of-Life, Tel Aviv University, Ramat Aviv, Israel Geriatric Division, The Chaim Sheba Medical Center, Tel Hashomer, Israel
出版信息
Am J Alzheimers Dis Other Demen. 2016 Mar;31(2):169-80. doi: 10.1177/1533317515598858. Epub 2015 Aug 19.
We studied 183 patients with advanced dementia who had been admitted to the Geriatric-Internal Medicine Department of a general hospital, with a 1 year follow-up evaluated by Mini-Suffering State Examination (MSSE) scores on first days after admission. The not calm compared to calm patients with advanced dementia had a high suffering level (6.12 ± 2.16 versus 3.21 ± 1.71) with a statistically significant difference (P = 0.001). The not calm patients were sicker, a higher percentage had fever (P = 0.005), elevated levels of white blood cells WBC (P = 0.003) and C-reactive protein (CRP) (P = 0.020). The Kaplan-Meier function analysis showed a shorter survival of not calm versus calm advanced dementia patients, with a statistically significant difference (Log Rank [Mantel-Cox] P = 0.002). Not calm in advanced dementia patients is the first item of the MSSE and is a very important symptom of Aminoff Suffering Syndrome.
我们研究了183例入住综合医院老年内科的晚期痴呆患者，在入院后首日通过简易痛苦状态检查（MSSE）评分进行为期1年的随访评估。与平静的晚期痴呆患者相比，不平静的患者痛苦程度较高（6.12±2.16对3.21±1.71），差异具有统计学意义（P = 0.001）。不平静的患者病情更严重，发热百分比更高（P = 0.005），白细胞（WBC）水平升高（P = 0.003），C反应蛋白（CRP）水平升高（P = 0.020）。Kaplan-Meier生存分析显示，不平静的晚期痴呆患者较平静患者生存期更短，差异具有统计学意义（对数秩检验[Mantel-Cox] P = 0.002）。晚期痴呆患者的不平静是MSSE的首要项目，也是阿明诺夫痛苦综合征的一个非常重要的症状。
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