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治疗肌萎缩侧索硬化症和亨廷顿舞蹈症潜在靶点概述

An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's Disease.

作者信息

de Paula Caroline Zocatelli, Gonçalves Bruno Daniel Correia, Vieira Luciene Bruno

机构信息

Laboratório de Neurofarmacologia, Departamento de Farmacologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais, Campus Pampulha, 31270901 Belo Horizonte, MG, Brazil.

出版信息

Biomed Res Int. 2015;2015:198612. doi: 10.1155/2015/198612. Epub 2015 Jul 29.

DOI:10.1155/2015/198612
PMID:26295035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4532815/
Abstract

Neurodegenerative diseases affect millions of people worldwide. Progressive damage or loss of neurons, neurodegeneration, has severe consequences on the mental and physical health of a patient. Despite all efforts by scientific community, there is currently no cure or manner to slow degeneration progression. We review some treatments that attempt to prevent the progress of some of major neurodegenerative diseases: Amyotrophic Lateral Sclerosis and Huntington's disease.

摘要

神经退行性疾病影响着全球数百万人。神经元的渐进性损伤或丧失,即神经退行性变,会对患者的身心健康造成严重后果。尽管科学界做出了种种努力,但目前尚无治愈方法或减缓退行性变进程的方式。我们回顾了一些试图阻止某些主要神经退行性疾病进展的治疗方法:肌萎缩侧索硬化症和亨廷顿舞蹈症。

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本文引用的文献

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Protective actions of melatonin and growth hormone on the aged cardiovascular system.褪黑素和生长激素对老年心血管系统的保护作用。
Horm Mol Biol Clin Investig. 2014 May;18(2):79-88. doi: 10.1515/hmbci-2014-0016.
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The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature.褪黑素促进健康睡眠的有效性:文献快速证据评估
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Melatonergic drugs in development.正在研发的褪黑素能药物。
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Neuroprotective agents target molecular mechanisms of disease in ALS.神经保护剂针对 ALS 中的疾病分子机制。
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Physiology (Bethesda). 2014 Sep;29(5):325-33. doi: 10.1152/physiol.00011.2014.
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The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease.mGluR5 正变构调节剂 CDPPB 改善亨廷顿病小鼠模型的病理和表型特征。
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Mitochondrial oxidative phosphorylation transcriptome alterations in human amyotrophic lateral sclerosis spinal cord and blood.人类肌萎缩侧索硬化症脊髓和血液中线粒体氧化磷酸化转录组的改变
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Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis.治疗肌萎缩侧索硬化症的潜在治疗药物和方法。
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