Shagina N B, Fell T P, Tolstykh E I, Harrison J D, Degteva M O
Urals Research Centre for Radiation Medicine, Chelyabinsk, 454076 Russia.
J Radiol Prot. 2015 Sep;35(3):659-76. doi: 10.1088/0952-4746/35/3/659. Epub 2015 Aug 21.
A biokinetic model for strontium (Sr) for the pregnant woman and fetus (Sr-PWF model) has been developed for use in the quantification of doses from internal radiation exposures following maternal ingestion of Sr radioisotopes before or during pregnancy. The model relates in particular to the population of the Techa River villages exposed to significant amounts of ingested Sr radioisotopes as a result of releases of liquid radioactive wastes from the Mayak plutonium production facility (Russia) in the early 1950s. The biokinetic model for Sr metabolism in the pregnant woman was based on a biokinetic model for the adult female modified to account for changes in mineral metabolism during pregnancy. The model for non-pregnant females of all ages was developed earlier with the use of extensive data on (90)Sr-body measurements in the Techa Riverside residents. To determine changes in model parameter values to take account of changing mineral metabolism during pregnancy, data from longitudinal studies of calcium homeostasis during human pregnancy were analysed and applied. Exchanges between maternal and fetal circulations and retention in fetal skeleton and soft tissues were modelled as adaptations of previously published models, taking account of data on Sr and calcium (Ca) metabolism obtained in Russia (Southern Urals and Moscow) relating to dietary calcium intakes, calcium contents in maternal and fetal skeletons and strontium transfer to the fetus. The model was validated using independent data on (90)Sr in the fetal skeleton from global fallout as well as unique data on (90)Sr-body burden in mothers and their still-born children for Techa River residents. While the Sr-PWF model has been developed specifically for ingestion of Sr isotopes by Techa River residents, it is also more widely applicable to maternal ingestion of Sr radioisotopes at different times before and during pregnancy and different ages of pregnant women in a general population.
已开发出一种针对孕妇和胎儿的锶（Sr）生物动力学模型（Sr-PWF模型），用于量化孕妇在怀孕前或怀孕期间摄入Sr放射性同位素后因内照射而产生的剂量。该模型特别适用于20世纪50年代初因俄罗斯马亚克钚生产设施排放液态放射性废物而摄入大量Sr放射性同位素的捷恰河流域村庄的人群。孕妇体内Sr代谢的生物动力学模型基于对成年女性生物动力学模型的修改，以考虑怀孕期间矿物质代谢的变化。所有年龄段非孕妇的模型是早些时候利用捷恰河畔居民大量的（90）Sr人体测量数据开发的。为了确定模型参数值的变化以考虑怀孕期间不断变化的矿物质代谢，对人类怀孕期间钙稳态的纵向研究数据进行了分析并应用。母体和胎儿循环之间的交换以及胎儿骨骼和软组织中的滞留被建模为先前发表模型的改编，同时考虑了在俄罗斯（南乌拉尔和莫斯科）获得的与膳食钙摄入量、母体和胎儿骨骼中的钙含量以及锶向胎儿的转移有关的Sr和钙（Ca）代谢数据。该模型使用来自全球沉降物中胎儿骨骼中（90）Sr的独立数据以及捷恰河居民母亲及其死产儿中（90）Sr体内负荷的独特数据进行了验证。虽然Sr-PWF模型是专门为捷恰河居民摄入Sr同位素而开发的，但它也更广泛地适用于一般人群中孕妇在怀孕前和怀孕期间不同时间以及不同年龄摄入Sr放射性同位素的情况。
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