Blau Jenny E, Collins Michael T
Program of Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, 20892, USA.
Rev Endocr Metab Disord. 2015 Jun;16(2):165-74. doi: 10.1007/s11154-015-9318-z.
Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. In this review, we discuss the genomic structure, and transcriptional, translational, and posttranslational regulation of FGF23. We describe its interaction with PTH and vitamin D, disorders of altered FGF23 states, and emerging therapies for diseases of FGF23 based upon these findings. This discussion helps redefine the role of PTH and vitamin D in relation to a complex bone-kidney-parathyroid loop, and points to areas within this complicated field in need of further clarification and research.
成纤维细胞生长因子23（FGF23）已成为磷酸盐和维生素D稳态的重要调节因子。了解FGF23如何在FGF23-维生素D-甲状旁腺激素（PTH）轴中与维生素D和甲状旁腺激素相互作用以调节矿物质稳态非常重要。在这篇综述中，我们讨论了FGF23的基因组结构、转录、翻译和翻译后调控。我们描述了它与PTH和维生素D的相互作用、FGF23状态改变的疾病，以及基于这些发现的FGF23相关疾病的新兴治疗方法。这一讨论有助于重新定义PTH和维生素D在复杂的骨-肾-甲状旁腺环路中的作用，并指出这一复杂领域中需要进一步阐明和研究的领域。
