Department of Biology Education, College of Education, Chungbuk National University, Chungbuk 361-763, Republic of Korea; College of Pharmacy, Chungbuk National University, Chungbuk 361-763, Republic of Korea.
Department of Biology Education, College of Education, Chungbuk National University, Chungbuk 361-763, Republic of Korea.
Int Immunopharmacol. 2015 Oct;28(2):977-84. doi: 10.1016/j.intimp.2015.08.014. Epub 2015 Aug 20.
Sesamolin and sesamin are representative lignans found in sesame seed. The present study was designed to demonstrate the anti-cancer activity of sesamolin achieved by increasing the expression level of NKG2D ligands on Raji cells, which are derived from Burkitt's lymphoma. The anti-cancer activity of sesamolin was also compared with that of sesamin. The cytolysis activity of NK cells against Raji was elevated by the pretreatment of sesamolin on Raji, but not by sesamin. We found that higher NKG2D ligand expression increased the sensitivity of sesamolin-treated Raji to NK cell lysis, resulting from a more active ERK signaling pathway. Our results provide evidence that targeting the ERK signaling pathway may enhance the antitumor activity of lignans and that there is a potential immunotherapeutic value for cancer treatment.
芝麻林和芝麻素是芝麻中代表性的木脂素。本研究旨在证明芝麻林通过增加源自伯基特淋巴瘤的 Raji 细胞上 NKG2D 配体的表达水平来实现抗癌活性。芝麻林的抗癌活性也与芝麻素进行了比较。芝麻林预处理 Raji 可提高 NK 细胞对 Raji 的细胞溶解活性，但芝麻素则没有。我们发现，更高水平的 NKG2D 配体表达增加了芝麻林处理后的 Raji 对 NK 细胞裂解的敏感性，这是由于 ERK 信号通路更为活跃。我们的结果提供了证据表明，靶向 ERK 信号通路可能增强木脂素的抗肿瘤活性，并且对癌症治疗具有潜在的免疫治疗价值。
