Eltohami E A, Akl K F
Br J Clin Pract. 1989 Oct;43(10):366-8.
Sixty-two children with primary nephrotic syndrome were studied. The mean age at diagnosis was 5.5 years (range 1.5-11 years). Fifty-five were initially steroid sensitive (88.7 per cent) and seven (11.2 per cent) were steroid resistant. Renal biopsies performed on six of the steroid-resistant cases showed focal glomerulosclerosis in three, minimal change disease in two and membranoproliferative glomerulonephritis in one. Of the 55 children who were initially steroid responsive, 12 (21.8 per cent) had a frequently relapsing course, while three (5.5 per cent) became steroid resistant. Two out of the 12 who had frequent relapses became steroid resistant and one became steroid dependent. Renal biopsies performed on six of these patients showed minimal change disease in five and segmental glomerulosclerosis in one. Renal biopsies of two out of three patients who were initially steroid responsive but who later became resistant showed minimal change disease in one and segmental sclerosis in one.
对62例原发性肾病综合征患儿进行了研究。诊断时的平均年龄为5.5岁（范围1.5 - 11岁）。55例最初对类固醇敏感（88.7%），7例（11.2%）对类固醇耐药。对6例类固醇耐药病例进行的肾活检显示，3例为局灶性节段性肾小球硬化，2例为微小病变病，1例为膜增生性肾小球肾炎。在最初对类固醇有反应的55例儿童中，12例（21.8%）病程频繁复发，而3例（5.5%）对类固醇耐药。在12例频繁复发的患儿中，2例对类固醇耐药，1例对类固醇依赖。对其中6例患者进行的肾活检显示，5例为微小病变病，1例为节段性肾小球硬化。最初对类固醇有反应但后来耐药的3例患者中，2例的肾活检显示1例为微小病变病，1例为节段性硬化。
