Development of renal insufficiency after long-standing steroid-responsive nephrotic syndrome.

In this report, we describe the case of a boy who developed the nephrotic syndrome at one and one-half years of age, remained steroid-responsive for nine years, but then became steroid-resistant, associated with the development of progressive glomerular sclerosis and renal insufficiency. We suggest that this evolution is evidence in favor of the view that minimal change disease and focal glomerulosclerosis have a common pathogenesis.